SLC35C1 Antibody, Biotin conjugated

說明書

中文名稱：

SLC35C1兔多克隆抗體, Biotin偶聯(lián)
貨號：

CSB-PA839285LD01HU
規(guī)格：

￥880
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關產(chǎn)品
靶點詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) SLC35C1 Polyclonal antibody
Uniprot No.：

Q96A29
基因名：

SLC35C1
別名：

SLC35C1 antibody; FUCT1GDP-fucose transporter 1 antibody; Solute carrier family 35 member C1 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human GDP-fucose transporter 1 protein (287-364AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Biotin
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產(chǎn)品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

Involved in GDP-fucose import from the cytoplasm into the Golgi lumen.
基因功能參考文獻：
1. two Turkish siblings with a novel mutation in GDP-fucose transporter and features of congenital disorder of glycosylation IIc PMID: 25239688
2. Fx enzyme and GDP-L-Fuc Tr overexpression in the tumur tissue of colorectal cancer (CRC) patients suggests that GDP-L-Fuc transport to the Golgi apparatus may be an important factor associated with increased alpha(1,6)fucosylation in CRC. PMID: 23730929
3. In the rare LAD-II disease, the fucosylation of selectin ligands is disturbed, caused by mutations in SLC35C1, the gene that encodes a GDP-fucose transporter of the Golgi system. (Review) PMID: 22134107
4. the conserved glycine residues at positions 180 and 277 of SLC35C1 have significant impacts on lectin binding PMID: 22492235
5. In the GDP-fucose transporter a new single nucleotide deletion produced an open-reading frame shift & polypeptide truncation. Overexpression of the mutant protein in fibroblasts did not rescue fucosylation. The deletion ablated transporter activity. PMID: 12406889
6. Leukocyte adhesion deficiency II patients display dual defect in functoin ang Golgi expression of FUCT1. PMID: 16455955
7. the upregulation of GDP-Fuc Tr plays a pivotal role in increased fucosylation in hepatocellular carcinoma PMID: 17884843
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相關疾病：

Congenital disorder of glycosylation 2C (CDG2C)
亞細胞定位：

Golgi apparatus membrane; Multi-pass membrane protein.
蛋白家族：

TPT transporter family, SLC35C subfamily
數(shù)據(jù)庫鏈接：

HGNC: 20197

OMIM: 266265

KEGG: hsa:55343

STRING: 9606.ENSP00000313318

UniGene: Hs.12211

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