SH3BP5 Antibody

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) SH3BP5 Polyclonal antibody
Uniprot No.：

O60239
基因名：

SH3BP5
別名：

3BP5_HUMAN antibody; OTTHUMP00000208289 antibody; OTTHUMP00000208291 antibody; OTTHUMP00000208294 antibody; SAB antibody; SH3 binding protein antibody; SH3 domain binding protein 5 (BTK associated) antibody; SH3 domain binding protein 5 antibody; SH3 domain binding protein that preferentially associates with BTK antibody; SH3 domain-binding protein 5 antibody; SH3 domain-binding protein that preferentially associates with BTK antibody; SH3 domainbinding protein 5 antibody; SH3BP 5 antibody; SH3BP-5 antibody; Sh3bp5 antibody
宿主：

Rabbit
反應種屬：

Human, Mouse
免疫原：

Recombinant Human SH3 domain-binding protein 5 protein (49-455AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，SH3BP5 Antibody (CSB-PA021226LA01HU)，的標記方式是Non-conjugated。對于SH3BP5 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA021226LB01HU	SH3BP5 Antibody, HRP conjugated	ELISA
FITC	CSB-PA021226LC01HU	SH3BP5 Antibody, FITC conjugated
Biotin	CSB-PA021226LD01HU	SH3BP5 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC, IF

推薦稀釋比：

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Functions as guanine nucleotide exchange factor (GEF) with specificity for RAB11A and RAB25. Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death.
基因功能參考文獻：
1. SH3BP5, LMO3, and SNAP25 were expressed in diffuse large B-cell lymphoma cells and associated with clinical features. PMID: 27184832
2. REI/SH3BP5 protein family is conserved in evolution and is a group of new guanine nucleotide exchange factors for Rab11. PMID: 26745340
3. The interplay of p-JNK with mitochondrial Sab leads to impaired respiration, ROS production, sustained JNK activation, and apoptosis. PMID: 25666017
4. SH3BP5 binds to JNK and directly inhibits JNK through its two putative mitogen-activated protein kinase interaction motifs (KIMs). PMID: 23861391
5. mitochondrial protein Sab is phosphorylated by stress-activated protein kinase 3 PMID: 15158451
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亞細胞定位：

Cytoplasmic vesicle membrane; Peripheral membrane protein. Mitochondrion.
蛋白家族：

SH3BP5 family
組織特異性：

Highly expressed in testis and ovaries. It is also expressed in a variety of tissues including spleen, lymph node, thymus, bone marrow, fetal liver, colon, small intestine and prostate.
數據庫鏈接：

HGNC: 10827

OMIM: 605612

KEGG: hsa:9467

STRING: 9606.ENSP00000373301

UniGene: Hs.257761

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