SH3BP5 Antibody
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中文名稱：SH3BP5兔多克隆抗體
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貨號：CSB-PA021226GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：SH3BP5
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別名：3BP5_HUMAN antibody; OTTHUMP00000208289 antibody; OTTHUMP00000208291 antibody; OTTHUMP00000208294 antibody; SAB antibody; SH3 binding protein antibody; SH3 domain binding protein 5 (BTK associated) antibody; SH3 domain binding protein 5 antibody; SH3 domain binding protein that preferentially associates with BTK antibody; SH3 domain-binding protein 5 antibody; SH3 domain-binding protein that preferentially associates with BTK antibody; SH3 domainbinding protein 5 antibody; SH3BP 5 antibody; SH3BP-5 antibody; Sh3bp5 antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Human SH3BP5
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,WB,IHC
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Functions as guanine nucleotide exchange factor (GEF) with specificity for RAB11A and RAB25. Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death.
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基因功能參考文獻：
- SH3BP5, LMO3, and SNAP25 were expressed in diffuse large B-cell lymphoma cells and associated with clinical features. PMID: 27184832
- REI/SH3BP5 protein family is conserved in evolution and is a group of new guanine nucleotide exchange factors for Rab11. PMID: 26745340
- The interplay of p-JNK with mitochondrial Sab leads to impaired respiration, ROS production, sustained JNK activation, and apoptosis. PMID: 25666017
- SH3BP5 binds to JNK and directly inhibits JNK through its two putative mitogen-activated protein kinase interaction motifs (KIMs). PMID: 23861391
- mitochondrial protein Sab is phosphorylated by stress-activated protein kinase 3 PMID: 15158451
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亞細胞定位：Cytoplasmic vesicle membrane; Peripheral membrane protein. Mitochondrion.
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蛋白家族：SH3BP5 family
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組織特異性：Highly expressed in testis and ovaries. It is also expressed in a variety of tissues including spleen, lymph node, thymus, bone marrow, fetal liver, colon, small intestine and prostate.
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數據庫鏈接：
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