SCN2B Antibody

說明書

產品詳情

Uniprot No.：

O60939
基因名：

SCN2B
別名：

SCN2B; UNQ326/PRO386; Sodium channel subunit beta-2
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Human SCN2B
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產品提供形式：

Liquid
應用范圍：

ELISA,WB
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli. Interacts with TNR may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier.
基因功能參考文獻：
1. Findings add to the understanding of beta2 role in Nav 1.5 trafficking and localisation, which must influence cell excitability and electrical coupling in the heart. PMID: 28597987
2. The authors identified a flexible loop formed by (72)Cys and (75)Cys, a unique feature among the four beta-subunit isoforms. PMID: 26894959
3. With increased beta-2 expression, prostate cancer cells display a trend of enhanced association with nerve axons. PMID: 24892658
4. SCN2B is a new candidate gene associated with Brugada syndrome. PMID: 23559163
5. beta2 is a PS/gamma-secretase substrate, gamma-secretase mediated cleavage of beta2-C-terminal fragment is required for cell-cell adhesion and migration of beta2-expressing cells PMID: 15833746
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相關疾病：

Atrial fibrillation, familial, 14 (ATFB14)
亞細胞定位：

Membrane; Single-pass type I membrane protein.
蛋白家族：

Sodium channel auxiliary subunit SCN2B (TC 8.A.17) family
組織特異性：

Brain specific.
數據庫鏈接：

HGNC: 10589

OMIM: 601327

KEGG: hsa:6327

STRING: 9606.ENSP00000278947

UniGene: Hs.129783

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