RPS6KA2 Antibody

說明書

中文名稱：

RPS6KA2兔多克隆抗體
貨號：

CSB-PA040257
規(guī)格：

￥1090
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

Uniprot No.：

Q15349
基因名：

RPS6KA2
別名：

90 kDa ribosomal protein S6 kinase 2 antibody; HU 2 antibody; KS6A2_HUMAN antibody; MAP kinase activated protein kinase 1c antibody; MAP kinase-activated protein kinase 1c antibody; MAPK-activated protein kinase 1c antibody; MAPKAP kinase 1c antibody; MAPKAPK-1c antibody; MAPKAPK1C antibody; Mitogen.activated protein kinase-activated protein kinase 1C antibody; p90 RSK3 antibody; p90-RSK 2 antibody; p90RSK2 antibody; pp90RSK3 antibody; Ribosomal protein S6 kinase alpha-2 antibody; ribosomal protein S6 kinase; 90kDa; polypeptide 2 antibody; Ribosomal S6 kinase 3 antibody; RPS6KA2 antibody; RSK 3 antibody; RSK antibody; RSK-3 antibody; S6K alpha antibody; S6K alpha 2 antibody; S6K-alpha-2 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human,Mouse
免疫原：

Synthesized peptide derived from the Internal region of Human Rsk-3.
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

IHC, ELISA

推薦稀釋比：

Application	Recommended Dilution
IHC	1:100-1:300
ELISA	1:20000

Protocols：

Immunohistochemistry (IHC) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells.
基因功能參考文獻：
1. Data suggest that millisecond dynamic changes in PDZ1 domain conformation are responsible for higher affinity of scribble PDZ1 for phosphorylated ligands; oligopeptide fragments of RPS6KA2 and MCC were used as ligands in these nuclear magnetic resonance chemical shift experiments. (RPS6KA2 = ribosomal protein S6 kinase 2; MCC = mutated in colorectal cancer protein) PMID: 29144123
2. Data indicate that S6 kinase 2 (S6K2) can phosphorylate histone H3 at position Thr45, which may play a role during cell proliferation and/or differentiation. PMID: 23564320
3. Kinome screening revealed RPS6KA2 expression, in human pancreatic cancer cells, protects against erlotinib induced apoptosis. PMID: 24403857
4. genetic association study in Han population in China: Data suggest that SNPs in RSK3 (rs2229712) and in MEK1 (rs28730804) demonstrate gene-gene interaction that affects antidepressant drug outcome in female patients with major depressive disorder. PMID: 23727904
5. Overexpression of RSK3 or RSK4 supports tumor cell proliferation upon PI3K inhibition both in vitro and in vivo therby contributing to drug resistance. PMID: 23635776
6. p90RSK2 is dispensable for BCR-ABL-induced myeloid leukemia, but may be required for pathogenesis and lineage determination in FLT3-internal tandem duplication-induced hematopoietic transformation. PMID: 21527514
7. Characterization of the terminal domain as a protein kinase PMID: 12016217
8. chronic activation CREB and p90RSK in the epileptic hippocampus may be closely associated with the histopathological changes of Ammon's horn sclerosis PMID: 14646589
9. The accumulation of S6K2 in the nuclei of cancer cells and the correlation with the expression of PCNA and Ki-67 suggest the involvement of S6K2 in the regulation of malignant growth PMID: 15995633
10. p90Rsk-mediated modulation of Hdm2 nuclear is linked to cytoplasmic shuttling with the diminished ability of p53 to regulate cell cycle checkpoints that ultimately leads to transformation PMID: 16621805
11. The above results suggest that RPS6KA2 is a putative tumour suppressor gene to explain allele loss at 6q27. PMID: 16878154
12. there is a functional link between S6K1 II and CK2 signaling, which involves the regulation of S6K1 II nuclear export by CK2-mediated phosphorylation of Ser-17 PMID: 16895915
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亞細胞定位：

Nucleus. Cytoplasm.
蛋白家族：

Protein kinase superfamily, AGC Ser/Thr protein kinase family, S6 kinase subfamily
組織特異性：

Widely expressed with higher expression in lung, skeletal muscle, brain, uterus, ovary, thyroid and prostate.
數(shù)據(jù)庫鏈接：

HGNC: 10431

OMIM: 601685

KEGG: hsa:6196

STRING: 9606.ENSP00000427015

UniGene: Hs.655277

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