RNF40 Antibody

中文名稱：

RNF40兔多克隆抗體
貨號(hào)：

CSB-PA019890LA01HU
規(guī)格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA019890LA01HU at dilution of 1:100
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
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靶點(diǎn)詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) RNF40 Polyclonal antibody
Uniprot No.：

O75150
基因名：

RNF40
別名：

95 kDa retinoblastoma associated protein antibody; 95 kDa retinoblastoma protein binding protein antibody; 95 kDa retinoblastoma-associated protein antibody; BRE 1B antibody; BRE1 B antibody; BRE1 E3 ubiquitin ligase homolog B antibody; BRE1-B antibody; BRE1B antibody; BRE1B_HUMAN antibody; DKFZp686K191 antibody; E3 ubiquitin protein ligase BRE1B antibody; E3 ubiquitin-protein ligase BRE1B antibody; KIAA0661 antibody; MGC13051 antibody; Rb associated protein antibody; RBP 95 antibody; RBP95 antibody; RING finger protein 40 antibody; Ring finger protein 40 E3 ubiquitin protein ligase antibody; RNF 40 antibody; Rnf40 antibody; STARING antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human E3 ubiquitin-protein ligase BRE1B protein (471-724AA)
免疫原種屬：

Homo sapiens (Human)

標(biāo)記方式：

Non-conjugated

本頁面中的產(chǎn)品，RNF40 Antibody (CSB-PA019890LA01HU)，的標(biāo)記方式是Non-conjugated。對(duì)于RNF40 Antibody，我們還提供其他標(biāo)記。見下表：

標(biāo)記方式	貨號(hào)	產(chǎn)品名稱	應(yīng)用
HRP	CSB-PA019890LB01HU	RNF40 Antibody, HRP conjugated	ELISA
FITC	CSB-PA019890LC01HU	RNF40 Antibody, FITC conjugated
Biotin	CSB-PA019890LD01HU	RNF40 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes.
基因功能參考文獻(xiàn)：
1. the RNF20/40 complex, a major ubiquitin ligase catalysing histone H2B monoubiquitination, interacts with the motor protein Eg5 during mitosis and participates in spindle assembly. PMID: 27557628
2. The authors also show that the RING domains of RNF20 and RNF40 can form a stable heterodimer that is active. PMID: 27569044
3. Manipulation of key H2Bub1 E3 ubiquitin ligases, RNF20, RNF40 and BRCA1, in ovarian cancer cell line models modulated H2Bub1 levels, indicative of the role of these RING finger ligases in monoubiquitination of H2Bub1 in vitro PMID: 27798111
4. We show that Bre1 (human BRE1A/B (RNF20/40) and mouse Bre1a/b (Rnf20/40)) acts as an important suppressor of chromosomal instability PMID: 22354749
5. our results suggest that RNF20 and RNF40, either via ubiquitylation of H2B or other targets, are coupled to the proliferation of prostate cancer cells. PMID: 22155569
6. RNF40 cooperates with SUPT16H to induce dynamic changes in chromatin structure during DNA double-strand break repair. PMID: 22031019
7. the observed defects in the radiation response of Bre1a/b-deficient cells PMID: 20738173
8. Formation of trimeric complex UbcH6 and RNF20/40 with PAF stimulates histone 2B monoubiquitination activity in vitro PMID: 16307923
9. Functional Analysis of the rat counterpart PMID: 12121982
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亞細(xì)胞定位：

Nucleus.
蛋白家族：

BRE1 family
組織特異性：

Ubiquitously expressed. Expressed at higher level in testis, heart and pancreas, while it is only weakly expressed in lung, skeletal muscle and small intestine.
數(shù)據(jù)庫(kù)鏈接：

HGNC: 16867

OMIM: 607700

KEGG: hsa:9810

STRING: 9606.ENSP00000325677

UniGene: Hs.65238

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