RFXANK Antibody, HRP conjugated
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中文名稱：RFXANK兔多克隆抗體, HRP偶聯
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貨號：CSB-PA019617LB01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) RFXANK Polyclonal antibody
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Uniprot No.：
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基因名：
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別名：ANKRA1 antibody; Ankyrin repeat containing regulatory factor X associated protein antibody; Ankyrin repeat family A protein 1 antibody; BLS antibody; DNA-binding protein RFXANK antibody; F14150_1 antibody; MGC138628 antibody; Regulatory factor X associated ankyrin containing protein antibody; Regulatory factor X subunit B antibody; Regulatory factor X, ankyrin repeat containing antibody; Regulatory factor X-associated ankyrin-containing protein antibody; RFX Bdelta4 antibody; RFX-B antibody; RFXANK antibody; RFXB antibody; RFXB delta 4 antibody; RFXK_HUMAN antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human DNA-binding protein RFXANK protein (3-84AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：HRP
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Activates transcription from class II MHC promoters. Activation requires the activity of the MHC class II transactivator/CIITA. May regulate other genes in the cell. RFX binds the X1 box of MHC-II promoters. May also potentiate the activation of RAF1.; Isoform 2 is not involved in the positive regulation of MHC class II genes.
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基因功能參考文獻：
- mutation results in Bare Lymphocyte Syndrome, Type 2 in a child of Mexican descent PMID: 26634365
- genetic, clinical, and immunologic features of 35 patients from 30 unrelated kindreds from North Africa sharing the same RFXANK founder mutation, a 26-bp deletion called I5E6-25_I5E6 + 1) PMID: 21908431
- Findings confirm the association between the high frequency of the combined immunodeficiency and the defect in MHC class II expression and provides strong evidence for a founder effect of the 752delG26 mutation in the North African population. PMID: 20414676
- Low levels of RFX-B are found in macrophages of colorectal cancer patients, partly explaining immunodeficiency in cancer. PMID: 11836625
- in vivo effects of mutations on the expression of the RFXANK RNA and protein PMID: 12618906
- ANKRA, RFXANK, and CIITA are novel targets of class IIa HDACs which may deacetylases play a role in regulating MHCII expression PMID: 15964851
- analysis of RFXANK domains and function PMID: 16166641
- RFXAP and RFXB have roles in relieving autoinhibition of RFX5 PMID: 18723135
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相關疾病：Bare lymphocyte syndrome 2 (BLS2)
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亞細胞定位：Cytoplasm. Nucleus.
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組織特異性：Ubiquitous.
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