Phospho-WRN (S1141) Antibody
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中文名稱：磷酸化-WRN (S1141)兔多克隆抗體
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貨號：CSB-PA060086
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規格：￥1090
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其他：
產品詳情
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Uniprot No.：
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基因名：
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別名：DKFZp686C2056 antibody; DNA helicase antibody; DNA helicase, RecQ like type 3 antibody; Exonuclease WRN antibody; HGNC 12791 antibody; OTTHUMP00000225301 antibody; RecQ protein-like 2 antibody; RecQ-like type 3 antibody; RecQ3 antibody; RECQL2 antibody; RECQL3 antibody; Werner syndrome ATP-dependent helicase antibody; Werner syndrome helicase antibody; Werner syndrome protein antibody; Werner syndrome, RecQ helicase like antibody; WRN antibody; WRN_HUMAN antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Synthesized peptide derived from Human WRN around the phosphorylation site of S1141.
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產品提供形式：Liquid
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應用范圍：WB, ELISA
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 ELISA 1:5000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Multifunctional enzyme that has both magnesium and ATP-dependent DNA-helicase activity and 3'->5' exonuclease activity towards double-stranded DNA with a 5'-overhang. Has no nuclease activity towards single-stranded DNA or blunt-ended double-stranded DNA. Binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and Holliday junctions. May play an important role in the dissociation of joint DNA molecules that can arise as products of homologous recombination, at stalled replication forks or during DNA repair. Alleviates stalling of DNA polymerases at the site of DNA lesions. Important for genomic integrity. Plays a role in the formation of DNA replication focal centers; stably associates with foci elements generating binding sites for RP-A. Plays a role in double-strand break repair after gamma-irradiation.
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基因功能參考文獻：
- results indicate that WRN helicase activity alone is not rate-limiting for the development of clinical Werner syndrome. PMID: 28276523
- The acidic domain of WRNp was shown to affect the transcription of certain proteins involved in autophagy and aging. PMID: 29800817
- Data suggest that Werner syndrome helicase (WRN) promotes classical (c)-nonhomologous end joining (NHEJ) via helicase and exonuclease activities and inhibits alternative (alt)-NHEJ using non-enzymatic functions. PMID: 27922005
- A CDK1-dependent regulation of the WRN-DNA2-mediated resection and identify a new function of WRN as a DSB repair pathway switch are reported. PMID: 27634057
- In the Title. PMID: 28012115
- Data show that helicases RHAU, BLM, and WRN exhibit distinct G-quadruplex (GQ) conformation specificity, but use a common mechanism of repetitive unfolding that leads to disrupting GQ structure multiple times in succession. PMID: 27407146
- there was no consistent association between WRN promoter hypermethylation and loss of WRN expression at the mRNA or protein level in CRC cell lines or tumors. PMID: 27121793
- Low WRN expression is associated with aggressive tumor phenotype in breast cancer. PMID: 26959889
- WRN is essential for survival of ATLL cells PMID: 27829440
- The authors show that the helicase of hDNA2 functionally integrates with BLM or WRN helicases to promote double-stranded DNA degradation by forming a heterodimeric molecular machine. This collectively suggests that the human DNA2 motor promotes the enzyme's capacity to degrade double-stranded DNA in conjunction with BLM or WRN and thus promote the repair of broken DNA. PMID: 27612385
- In meta-analyses including 59,190 individuals in 5 studies, the hazard ratio for ischemic stroke for C1367R TT homozygotes versus CC/CT was 1.14 . The study suggests that common genetic variation in WRN is associated with increased risk of ischemic stroke in the general population. PMID: 28063943
- The findings suggest that the epidermis is among the tissue types that do not display symptoms of premature ageing caused by loss of function of wrn. This is in support that Werner's syndrome is a segmental progeroid syndrome. PMID: 27492502
- Active control of repetitive structural transitions between replication forks and Holliday junctions by WRN has been reported. PMID: 27427477
- Evaluation of localization of WRN signals demonstrated that WRN does not leave the nucleolus after irradiation. The WRN signal was not detected at the telomere sides, but H2AX was detected at the telomeric sides. Thus, the WRN protein is not involved in irradiation-induced DNA damage/repair, even at telomeric sides in human mesenchymal stem cells (hMSC) and hMSC-telomere 1. PMID: 28436335
- The proportion of compound heterozygotes (31.8%) was significantly greater than reported previously (14.2%), indicating that the incidence of consanguineous marriage of parents has decreased. One novel mutant allele was identified in an individual with the compound heterozygous genotype. PMID: 28394436
- In humans, mutations in WRN give rise to Werner syndrome characterized by premature development of features associated with aging. PMID: 27238185
- Werner syndrome is a prototypical segmental progeroid syndrome characterized by multiple features consistent with accelerated aging. It is caused by null mutations of the WRN gene, which encodes a member of the RECQ family of DNA helicases. PMID: 26993153
- Our results identify the human WRN RECQ protein as a G4 helicase that modulates gene expression in G4-dependent fashion at many chromosomal sites and provide several new and unexpected mechanistic insights into Werner syndrome (WS) disease pathogenesis PMID: 26984941
- WRN or the Bloom syndrome helicase (BLM) stimulates DNA polymerase delta progression across telomeric G-rich repeats, only WRN promotes sequential strand displacement synthesis and FEN1 cleavage. PMID: 27849570
- This study identified residues in the WRN RQC domain that are involved specifically in the interaction with G-quadruplex DNA. PMID: 28069813
- findings indicate that WRN interacts with HDACs 1 and 2 to facilitate activity of stalled replication forks under conditions of replication stress. PMID: 27672210
- We found statistically significant association with AAO for three genes (WRN, NTN4 and LAMC3) with common associated variants. PMID: 26394601
- Finfings indicate a role for Werner syndrome helicase WRN as a modulator of DNA repair, replication, and recombination. PMID: 26695548
- The WRN Cys1367Arg (T>C) polymorphism is not associated with overall cancer risk, although subgroup analyses suggested an association with breast cancer and overall cancer specifically in European populations. [meta-analysis] PMID: 25468760
- The CC genotype of WRN rs1346044 may contribute to an increased risk and a premature onset of breast cancer. PMID: 26690424
- Japanese subjects bearing at least one A allele of rs2230009 of the WRN gene are at a significantly higher risk of femoral fracture, possibly due to decreased bone density. PMID: 25637295
- WRN prefers to act on DNA strand invasion intermediates in a manner that favours strand invasion and exchange. PMID: 26420422
- we provide a proof of concept for applying the external guide sequence (EGS) approach in directing an RNase P RNA to efficiently cleave the WRN mRNA in cultured human cell lines. PMID: 26808708
- Multiplex genetic testing of 90 cancer susceptibility genes disclosed a novel WRN frameshift mutation (p.N1370Tfs*23) in a mother and her 2 daughters with cancer and in the youngest unaffected daughter. PMID: 26241669
- PARylation is involved in the recruitment of RECQL5 and WRN to laser-induced DNA damage and RECQL5 and WRN have differential responses to PARylated PARP1 and Poly(ADP-ribose). PMID: 26391948
- WRN knockdown decreased the G(O):A-induced A:T --> C:G mutations, suggesting that WRN may enhance the mutations caused by G(O) in the nucleotide pool PMID: 25730140
- a significant interaction with risk of overall Non Hodgkin lymphoma was observed between WRN rs1346044 and hair dye use before 1980. PMID: 25178586
- knockdown of WRN reduced TNF-alpha stimulation-induced activation of the endogenous promoter of IL-8, an NF-kappaB-responsive gene, and WRN increased its association with the IL-8 promoter region together with RelA/p50 after TNF-alpha stimulation PMID: 26037922
- Data indicate that Werner syndrome helicase (WRN)-mediated DNA repair is regulated by SIRT1 deacetylase. PMID: 25801465
- A nonenzymatic role for WRN in preserving nascent DNA strands following replication stress, is reported. PMID: 25456133
- our results provide first indication of nonredundant participation of WRN and RECQ1 in protection from potentially carcinogenic effects PMID: 25228686
- The extent to which heterozygosity at the WRN locus may modify the effect of biallelic SAMHD1 mutations is unknown. PMID: 24989684
- Data suggest that Werner protein (WRNp) may have a role in controlling autophagy and hereby cellular maintenance. PMID: 25257404
- The FEN1 E359K germline mutation disrupts the FEN1-WRN interaction and FEN1 GEN activity, causing aneuploidy-associated cancers. PMID: 24608430
- Results show increased autophagy in WRN knockdown cells; this was further increased by short-term rapamycin treatment. PMID: 24308646
- results are consistent with proposed metabolic roles for WRN and genomic instability phenotypes associated with WRN deficiency PMID: 24965941
- The study demonstrated that helicase/ATPase and exonuclease activities of 4-hydroxy-2-nonenal-modified WRN protein were inhibited both in vitro and in immunocomplexes purified from the cell extracts. PMID: 25170083
- Using long-term siRNA knockdown of WRN in three ALT cell lines, we show that some, but not all, cell lines require WRN for telomere maintenance. PMID: 24709898
- WRN and BLM act epistatically with DNA2 to promote the long-range resection of double strand break ends in human cells. PMID: 25122754
- Werner syndrome protein positively regulates XRCC4-like factor transcription. PMID: 24626809
- WRN plays a critical role in cancer cell proliferation by contributing to the Warburg effect and preventing metabolic stress. PMID: 24757718
- Indicate that phosphorylation of Ser-440 and -467 in WRN by DNA-PK is important for relocalization of WRN to nucleoli, and that it is required for efficient DSB repair. PMID: 24429382
- WRN promoter methylation was associated with irinotecan sensitivity in gastric carcinoma. PMID: 24359226
- C allele of rs1346044, a non-synonymous SNP resulting in the conversion of Cys to Arg at amino acid position 1367 of WRN, alters susceptibility to ARC, especially the cortical type of the disease, in the Han Chinese. PMID: 23334603
- A significant interaction of a DNA repair pathway gene WRN and body mass index was observed in T-cell lymphoma. PMID: 23619945
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相關疾?。?/div>Werner syndrome (WRN); Colorectal cancer (CRC)亞細胞定位：Nucleus, nucleolus. Nucleus. Nucleus, nucleoplasm. Chromosome.蛋白家族：Helicase family, RecQ subfamily數據庫鏈接：
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