WRN
WRN，即Werner綜合征蛋白，它是一種多功能的DNA解旋酶，屬于RecQ解旋酶家族的一員。WRN在細胞核中發揮作用，具有依賴于ATP的DNA解旋酶活性和3'端到5'端的外切酶活性。它的作用機制涉及到DNA復制、重組、損傷修復以及端粒的維護。WRN通過參與細胞周期調控和DNA修復信號通路，如與p53、RAD50、RAD51等蛋白相互作用，調節細胞對DNA損傷的響應。WRN的生物學意義在于維持基因組的完整性和穩定性，防止早衰和某些類型的癌癥。WRN基因的突變與Werner綜合征相關，這是一種早老性疾病，患者會經歷加速的衰老過程和較高的癌癥風險。
熱銷產品
驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
WRN Antibodies
WRN for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA060086 | Phospho-WRN (S1141) Antibody | Human | WB, ELISA |
WRN Proteins
WRN Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP614518HU CSB-EP614518HU CSB-BP614518HU CSB-MP614518HU CSB-EP614518HU-B |
Recombinant Human Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (WRN), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP614518HU1 | Recombinant Human Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (WRN), partial | E.coli |
| CSB-EP614518HU1a0 | Recombinant Human Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (WRN), partial | E.coli |
| CSB-EP614518HU1d8 | Recombinant Human Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (WRN), partial | E.coli |
| CSB-BP614518HU3 | Recombinant Human Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (WRN), partial | Baculovirus |
