Phospho-STMN2 (S73) Antibody

說明書

中文名稱：

磷酸化-STMN2 (S73)兔多克隆抗體
貨號：

CSB-PA006764
規格：

￥1090
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

Q93045
基因名：

STMN2
別名：

Neuron specific growth associated protein antibody; Neuronal growth associated protein antibody; Neuronal growth associated protein (silencer element) antibody; Protein SCG10 antibody; SCG 10 antibody; SCG10 antibody; SCG10 protein antibody; SCGN 10 antibody; SCGN10 antibody; SGC 10 antibody; SGC10 antibody; Stathmin 2 antibody; Stathmin like 2 antibody; Stathmin-2 antibody; STMN 2 antibody; STMN2 antibody; STMN2_HUMAN antibody; Superior cervical ganglia neural specific 10 antibody; Superior cervical ganglion 10 protein antibody; Superior cervical ganglion-10 protein antibody; Superiorcervical ganglia neural specific 10 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Synthesized peptide derived from Human SCG10 around the phosphorylation site of S73.
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

IHC, ELISA

推薦稀釋比：

Application	Recommended Dilution
IHC	1:100-1:300
ELISA	1:5000

Protocols：

Immunohistochemistry (IHC) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Regulator of microtubule stability. When phosphorylated by MAPK8, stabilizes microtubules and consequently controls neurite length in cortical neurons. In the developing brain, negatively regulates the rate of exit from multipolar stage and retards radial migration from the ventricular zone.
基因功能參考文獻：
1. RARB and STMN2 polymorphisms were not associated with sporadic CJD in the Korean population. PMID: 24414001
2. STMN and SCG10 are similarly targeted by JNK but there are clear differences in JNK recognition and phosphorylation of the closely related family member, SCLIP. PMID: 24589734
3. SCG10 is upregulated in the IKAP/Elp1-deficient familial dysautonomia cerebrum lending support to the concept that SCG10 elevation can alter the microtubule organization and dynamics PMID: 21273291
4. Overexpression of SCG10 is associated with Liver Fibrosis. PMID: 20802173
5. RGS6 interacts with this protein and promotes neuronal differentiation; role of the G gamma subunit-like (GGL) domain of RGS6 PMID: 12140291
6. STMN2 is required for maintaining the anchorage-independent growth state of beta-catenin/TCF-activated hepatoma cells PMID: 16712787
7. activity at opposite microtubule ends may play role role in regulating growth cone microtubules; ability to promote plus end growth may facilitate microtubule extension; ability to destabilize minus ends may provide tubulin for net plus end elongation PMID: 17311410
8. Review proposes a model reconciling the microtubule regulatory properties of superior cervical ganglion protein 10 with its role as a c-Jun N-terminal kinase 1 (JNK1) effector of regeneration. PMID: 18076368
9. BRI3 associates with SCG10 and attenuates NGF-induced neurite outgrowth in PC12 cells. PMID: 18452648
10. SCLIP and SCG10 were colocalized to the Golgi apparatus of chromaffin cells in vivo and shared localization with CHGA as it transited the Golgi. PMID: 18549247
11. STMN2 appears a novel marker of osteogenesis and osteoblast per se, that could play a role in the regulation of the adipocyte/osteoblast balance. PMID: 18611392
12. SCG10 acts as an effector downstream of Rnd1 to regulate axon extensions by modulating microtubule organization. PMID: 18996843
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亞細胞定位：

Cytoplasm. Cytoplasm, perinuclear region. Cell projection, growth cone. Membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, axon. Golgi apparatus. Endosome. Cell projection, lamellipodium.
蛋白家族：

Stathmin family
組織特異性：

Neuron specific.
數據庫鏈接：

HGNC: 10577

OMIM: 600621

KEGG: hsa:11075

STRING: 9606.ENSP00000429243

UniGene: Hs.521651

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