Recombinant Human Stathmin-2 (STMN2)

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中文名稱：

Recombinant Human Stathmin-2 (STMN2)
貨號：

CSB-EP853100HU
說明書：

MSDS Datasheet
規格：

￥1536
圖片：
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
其他：

產品詳情
產品評價
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靶點詳情

產品詳情

純度：

Greater than 95% as determined by SDS-PAGE.
生物活性：

Not Test
基因名：

STMN2
Uniprot No.：

Q93045
別名：

Superior cervical ganglion-10 protein;Protein SCG10
種屬：

Homo sapiens (Human)
蛋白長度：

Full Length
來源：

E.coli
分子量：

27.7 kDa
表達區域：

1-179aa
氨基酸序列

MAKTAMAYKEKMKELSMLSLICSCFYPEPRNINIYTYDDMEVKQINKRASGQAFELILKPPSPISEAPRTLASPKKKDLSLEEIQKKLEAAEERRKSQEAQVLKQLAEKREHEREVLQKALEENNNFSKMAEEKLILKMEQIKENREANLAAIIERLQEKERHAAEVRRNKELQVELSG
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

C-terminal 6xHis-tagged
產品提供形式：

Liquid or Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

3-7 business days
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Datasheet & COA：

Please contact us to get it.

產品評價

靶點詳情

功能：

Regulator of microtubule stability. When phosphorylated by MAPK8, stabilizes microtubules and consequently controls neurite length in cortical neurons. In the developing brain, negatively regulates the rate of exit from multipolar stage and retards radial migration from the ventricular zone.
基因功能參考文獻：
1. RARB and STMN2 polymorphisms were not associated with sporadic CJD in the Korean population. PMID: 24414001
2. STMN and SCG10 are similarly targeted by JNK but there are clear differences in JNK recognition and phosphorylation of the closely related family member, SCLIP. PMID: 24589734
3. SCG10 is upregulated in the IKAP/Elp1-deficient familial dysautonomia cerebrum lending support to the concept that SCG10 elevation can alter the microtubule organization and dynamics PMID: 21273291
4. Overexpression of SCG10 is associated with Liver Fibrosis. PMID: 20802173
5. RGS6 interacts with this protein and promotes neuronal differentiation; role of the G gamma subunit-like (GGL) domain of RGS6 PMID: 12140291
6. STMN2 is required for maintaining the anchorage-independent growth state of beta-catenin/TCF-activated hepatoma cells PMID: 16712787
7. activity at opposite microtubule ends may play role role in regulating growth cone microtubules; ability to promote plus end growth may facilitate microtubule extension; ability to destabilize minus ends may provide tubulin for net plus end elongation PMID: 17311410
8. Review proposes a model reconciling the microtubule regulatory properties of superior cervical ganglion protein 10 with its role as a c-Jun N-terminal kinase 1 (JNK1) effector of regeneration. PMID: 18076368
9. BRI3 associates with SCG10 and attenuates NGF-induced neurite outgrowth in PC12 cells. PMID: 18452648
10. SCLIP and SCG10 were colocalized to the Golgi apparatus of chromaffin cells in vivo and shared localization with CHGA as it transited the Golgi. PMID: 18549247
11. STMN2 appears a novel marker of osteogenesis and osteoblast per se, that could play a role in the regulation of the adipocyte/osteoblast balance. PMID: 18611392
12. SCG10 acts as an effector downstream of Rnd1 to regulate axon extensions by modulating microtubule organization. PMID: 18996843
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亞細胞定位：

Cytoplasm. Cytoplasm, perinuclear region. Cell projection, growth cone. Membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, axon. Golgi apparatus. Endosome. Cell projection, lamellipodium.
蛋白家族：

Stathmin family
組織特異性：

Neuron specific.
數據庫鏈接：

HGNC: 10577

OMIM: 600621

KEGG: hsa:11075

STRING: 9606.ENSP00000429243

UniGene: Hs.521651