PTPRM Antibody

說明書

中文名稱：

PTPRM兔多克隆抗體
貨號：

CSB-PA364182
規格：

￥1100
圖片：
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CSB-PA364182(PTPRM Antibody) at dilution 1/80, on the right is treated with synthetic peptide. (Original magnification: ×200)

The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using CSB-PA364182(PTPRM Antibody) at dilution 1/80, on the right is treated with synthetic peptide. (Original magnification: ×200)
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

P28827
基因名：

PTPRM
別名：

tibody; hR PTPu antibody; Protein tyrosine phosphatase mu antibody; Protein tyrosine phosphatase mu precursor antibody; Protein tyrosine phosphatase receptor type M antibody; Protein tyrosine phosphatase receptor type mu polypeptide antibody; Protein-tyrosine phosphatase mu antibody; PTPRL1 antibody; Ptprm antibody; PTPRM protein antibody; PTPRM_HUMAN antibody; R PTP mu antibody; R-PTP-mu antibody; Receptor type tyrosine protein phosphatase mu antibody; Receptor-type tyrosine-protein phosphatase mu antibody; RPTP mu antibody; RPTPM antibody; RPTPU antibody
宿主：

Rabbit
反應種屬：

Human,Mouse
免疫原：

Synthetic peptide of Human PTPRM
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

Antigen affinity purification
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
產品提供形式：

Liquid
應用范圍：

ELISA,IHC

推薦稀釋比：

Application	Recommended Dilution
ELISA	1:2000-1:10000
IHC	1:100-1:300

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Involved in cell-cell adhesion through homophilic interactions. May play a key role in signal transduction and growth control.
基因功能參考文獻：
1. Study determined that, in addition to the furin-processed form of PTPmicro, a pool of 200 kDa full-length PTPmicro exists at the plasma membrane that is cleaved directly by ADAM to generate a larger shed form of the PTPmicro extracellular segment. PMID: 24771611
2. Decreased expression of PTPRM in breast cancer is correlated with poor prognosis and inversely correlated with disease-free survival. PMID: 23185569
3. Loss of PTPmu by proteolysis causes glioblastoma. PMID: 22505657
4. Results suggest that miR-221 and -222 regulate glioma tumorigenesis at least in part through the control of PTPmu protein expression. PMID: 21743492
5. In A549 cells, diverse injurious stimuli dramatically reduced PTPmu protein expression. PMID: 21649524
6. Loss of protein tyrosine phosphatase receptor type mu is associated with glioma cell migration and progression. PMID: 19304959
7. RPTPmu may play a role in the regulation of cardiovascular functions PMID: 12895029
8. PTPmu may regulate Rho-GTPase-dependent functions of IQGAP1 PMID: 16380380
9. a 3.1 angstrom crystal structure of the RPTPmu ectodomain that forms a homophilic trans (antiparallel) dimer with an extended and rigid architecture, matching the dimensions of adherens junctions is described PMID: 17761881
10. BCCIP is phosphorylated by the Src tyrosine kinase and dephosphorylated by the PTPmu tyrosine phosphatase; neurite outgrowth assays suggest that BCCIP and PTPmu are in a common signal transduction pathway. PMID: 18773424
11. loss of cell surface PTPmu by proteolysis generates catalytically active PTPmu fragments that contribute to migration and survival of glioblastoma cells PMID: 19690139
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亞細胞定位：

Membrane; Single-pass type I membrane protein.
蛋白家族：

Protein-tyrosine phosphatase family, Receptor class 2B subfamily
數據庫鏈接：

HGNC: 9675

OMIM: 176888

KEGG: hsa:5797

STRING: 9606.ENSP00000331418

UniGene: Hs.49774

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