PRKAR2A Antibody
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中文名稱：PRKAR2A兔多克隆抗體
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貨號：CSB-PA018697LA01HU
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規格：￥440
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圖片：
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Western Blot
Positive WB detected in: Hela whole cell lysate, MCF-7 whole cell lysate, PC-3 whole cell lysate
All lanes: PRKAR2A antibody at 2.5µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 46, 44 kDa
Observed band size: 46 kDa -
Immunohistochemistry of paraffin-embedded human lymph node tissue using CSB-PA018697LA01HU at dilution of 1:100 -
Immunohistochemistry of paraffin-embedded human glioma using CSB-PA018697LA01HU at dilution of 1:100 -
Immunofluorescent analysis of HepG2 cells using CSB-PA018697LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) PRKAR2A Polyclonal antibody
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Uniprot No.：
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基因名：
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別名：cAMP dependent protein kinase regulatory subunit alpha 2 antibody; cAMP dependent protein kinase regulatory subunit RII alpha antibody; cAMP dependent protein kinase type II alpha regulatory chain antibody; cAMP dependent protein kinase type II alpha regulatory subunit antibody; cAMP-dependent protein kinase type II-alpha regulatory subunit antibody; KAP2 antibody; KAP2_HUMAN antibody; MGC3606 antibody; PKR 2 antibody; PKR2 antibody; PRKA R2 antibody; PRKAR 2 antibody; PRKAR2 antibody; PRKAR2A antibody; Protein kinase A RII alpha subunit antibody; Protein kinase cAMP dependent regulatory type II alpha antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human cAMP-dependent protein kinase type II-alpha regulatory subunit protein (43-205AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
本頁面中的產品，PRKAR2A Antibody (CSB-PA018697LA01HU)，的標記方式是Non-conjugated。對于PRKAR2A Antibody，我們還提供其他標記。見下表：
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA, WB, IHC, IF
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:5000 IHC 1:20-1:200 IF 1:50-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.
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基因功能參考文獻：
- High PK-R2 expression is associated with colorectal cancer. PMID: 26372733
- Prkar2a deficiency predisposes to hematopoietic malignancies in vivo. RIIalpha's likely association with HS and DLBCL was hitherto unrecognized and may lead to better understanding of these rare neoplasms. PMID: 26608815
- Disruption of Snapin-PKR2 interaction did not affect PKR2 signaling, but increased the ligand-induced degradation, implying a role of Snapin in the trafficking of PKR2. PMID: 26687946
- we demonstrate that neurochondrin has strong isoform selectivity towards the RIIa subunit of PKA with nanomolar affinity PMID: 25916936
- These data demonstrate that some Kallmann syndrome-associated, intracellularly retained mutant PKR2 receptors can be functionally rescued, suggesting a potential treatment strategy for patients bearing such mutations. PMID: 24753254
- Smad4 and the R subunit of the protein kinase A holoenzyme form a functional complex in vivo in response to TGFbeta. PMID: 23362281
- ETO nervy homology region (NHR) 3 domain-PKA(RIIalpha) protein interaction does not appear to significantly contribute to AML1-ETO's ability to induce leukemia. PMID: 20708017
- findings indicate that increased particulate type II protein kinase A activity occurs throughout pregnancy therefore directing the cAMP quiescence signal to specific subcellular loci within myometrial smooth muscle cells PMID: 12727975
- These data implicate the involvement of PKA-RIIalpha anchoring apical targeting of distinct proteins and glycosphingolipids to apical plasma membrane domains and suggest that rerouting may underlie the delayed Golgi-to-apical surface transport of MDR1. PMID: 16723498
- The high-resolution crystal structures of the docking and dimerization (D/D) domain of the RIIalpha regulatory subunit of PKA in complex with the high-affinity anchoring peptide AKAP-IS explain the molecular basis for AKAP-regulatory subunit recognition. PMID: 17081989
- The data suggest that centrosomal anchoring of RIIalpha and the interrelated subapical positioning of these centrosomes is required for oncostatin M-, but not cAMP-mediated, bile canalicular lumen development. PMID: 17494870
- RIIalpha releases Calpha upon elevated cAMP alone, dependent on autophosphorylation of the RIIalpha inhibitory domain PMID: 17884635
- Bacillus anthracis edema toxin altered the protein levels and activity of protein kinase A and exchange protein activated by cAMP (Epac), a recently identified cAMP-binding molecule. PMID: 19307216
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亞細胞定位：Cytoplasm. Cell membrane. Note=Colocalizes with PJA2 in the cytoplasm and the cell membrane.
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蛋白家族：CAMP-dependent kinase regulatory chain family
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組織特異性：Four types of regulatory chains are found: I-alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible.
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數據庫鏈接：
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