PPP2R5D Antibody

說明書

中文名稱：

PPP2R5D兔多克隆抗體
貨號：

CSB-PA143410
規格：

￥2024
圖片：
Western blot analysis of extracts from HuvEc cells and Jurkat cells, using PPP2R5D antibody.
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) PPP2R5D Polyclonal antibody
Uniprot No.：

Q14738
基因名：

PPP2R5D
宿主：

Rabbit
反應種屬：

Human
免疫原：

Synthesized peptide derived from internal of Human PPP2R5D.
免疫原種屬：

Homo sapiens (Human)
克隆類型：

Polyclonal
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
產品提供形式：

Liquid
應用范圍：

ELISA,WB

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:3000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
基因功能參考文獻：
1. Mutations in PPP2R5D are genetic cause of intellectual disability. PMID: 26576547
2. MiR-9 regulates GR signaling and steroid-resistant airway hyperresponsiveness by reducing protein phosphatase 2A activity. PMID: 25772595
3. Mutant B56delta was A and C binding-deficient, while mutant Aalpha subunits bound B56delta well but were unable to bind C PMID: 26168268
4. PP2A-B56delta is the single most significant contributor, of the PP2A holoenzyme subunits, to BubR1 and Bub1 kinetochore localization. PMID: 25246613
5. Protein kinase A mediated activation of protein phosphatase 2A is enabled by PPP2R5D phosphorylation, which modulates the affinity of the protein phosphatase 2A holoenzyme to its physiological substrates. PMID: 20423611
6. Data show that the protein phosphatase 2A subunit B56delta specifically interacts with HAND1 and -2, but not other basic helix-loop-helix proteins. PMID: 14636580
7. Gonadotropin-releasing hormone (GnRH) affects the membrane protein phosphatase 2A-associated apoptosis and the enzyme activity in ovarian cancer cells. PMID: 15809743
8. PP2A:B56delta as a key upstream regulator of Cdk1 activity upon exit from mitosis PMID: 18056802
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相關疾病：

Mental retardation, autosomal dominant 35 (MRD35)
亞細胞定位：

Cytoplasm. Nucleus. Note=Nuclear in interphase, nuclear during mitosis.
蛋白家族：

Phosphatase 2A regulatory subunit B56 family
組織特異性：

Isoform Delta-2 is widely expressed. Isoform Delta-1 is highly expressed in brain.
數據庫鏈接：

HGNC: 9312

OMIM: 601646

KEGG: hsa:5528

STRING: 9606.ENSP00000417963

UniGene: Hs.533308

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