PLXNA4 Antibody, HRP conjugated

說明書

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) PLXNA4 Polyclonal antibody
Uniprot No.：

Q9HCM2
基因名：

PLXNA4
別名：

FAYV2820 antibody; KIAA1550 antibody; PLEXA4 antibody; Plexin-A4 antibody; PlexinA4 antibody; PLXA4_HUMAN antibody; plxna4 antibody; PLXNA4A antibody; PLXNA4B antibody; PRO34003 antibody; UNQ2820/PRO34003 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Plexin-A4 protein (24-522AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

HRP
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Coreceptor for SEMA3A. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.
基因功能參考文獻：
1. Both CLU and PLXNA4 have been genetically associated with Alzheimer disease (AD) risk and our data thus provide a direct relationship between two AD risk genes. Our data suggest that increasing the levels of PLXNA4 or targeting CLU-PLXNA4 interactions may have therapeutic value in AD. PMID: 27378688
2. There is a significant association between Alzheimer's disease risk and SNPs in PLXNA4. PMID: 25043464
3. Rare variants in PLXNA4 and Parkinson's disease. PMID: 24244438
4. Plexin-A4 promotes tumor progression and tumor angiogenesis by enhancement of VEGF and bFGF signaling. PMID: 21832283
亞細胞定位：

Cell membrane; Single-pass type I membrane protein.
蛋白家族：

Plexin family
數據庫鏈接：

HGNC: 9102

OMIM: 604280

KEGG: hsa:91584

STRING: 9606.ENSP00000323194

UniGene: Hs.511454

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