PLAA Antibody
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中文名稱：PLAA兔多克隆抗體
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貨號：CSB-PA018107ESR1HU
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規格：￥440
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圖片：
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Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA018107ESR1HU at dilution of 1:100 -
Immunohistochemistry of paraffin-embedded human endometrial cancer using CSB-PA018107ESR1HU at dilution of 1:100
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) PLAA Polyclonal antibody
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Uniprot No.：
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基因名：
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別名：FLJ11281 antibody; FLJ12699 antibody; Glycerophosphatase antibody; OTTHUMP00000045176 antibody; Phospholipase A 2 activating protein antibody; Phospholipase A-2-activating protein antibody; Phospholipase A2 activating protein antibody; PLA2P antibody; Plaa antibody; PLAP antibody; PLAP_HUMAN antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Phospholipase A-2-activating protein (536-795AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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產品提供形式：Liquid
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應用范圍：ELISA, IHC
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推薦稀釋比：
Application Recommended Dilution IHC 1:20-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Plays a role in protein ubiquitination, sorting and degradation through its association with VCP. Involved in ubiquitin-mediated membrane proteins trafficking to late endosomes in an ESCRT-dependent manner, and hence plays a role in synaptic vesicle recycling. May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes. Plays a role in cerebellar Purkinje cell development. Positively regulates cytosolic and calcium-independent phospholipase A2 activities in a tumor necrosis factor alpha (TNF-alpha)- or lipopolysaccharide (LPS)-dependent manner, and hence prostaglandin E2 biosynthesis.
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基因功能參考文獻：
- In both human and mouse, hypomorphic mutations in the ubiquitin adaptor protein PLAA cause an infantile-lethal neurodysfunction syndrome with seizures. PMID: 28413018
- This study presented that Phospholipase A2-activating protein is associated with a novel form of leukoencephalopathy. PMID: 28007986
- This review provides evidence that 1,25-dihydroxy vitamin D3 stimulates PLA2 via PLAA and CaMKII, a process initiated by Pdia3/PLAA interaction, which further triggers CaMKII-dependent PLA2 activation. [review] PMID: 25448737
- Function assignment to conserved residues in mammalian alkaline phosphatases. PMID: 11937510
- PLAP inhibits sPLA2-triggered release of fatty acids from erythrocyte membranes PMID: 14499668
- identified one stimulatory element, with Sp1 binding sites, and one inhibitory element, in exon 1 of the plaa gene PMID: 18291623
- Structural basis for ubiquitin recognition by a novel domain from the human phospholipase A2-activating protein PMID: 19423704
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相關疾病：Neurodevelopmental disorder with progressive microcephaly, spasticity, and brain anomalies (NDMSBA)
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亞細胞定位：Nucleus. Cytoplasm. Cell junction, synapse.
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蛋白家族：WD repeat PLAP family
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數據庫鏈接：
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