PHOX2A Antibody, HRP conjugated
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中文名稱：PHOX2A兔多克隆抗體, HRP偶聯(lián)
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貨號(hào)：CSB-PA017940LB01HU
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規(guī)格：￥880
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其他：
產(chǎn)品詳情
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產(chǎn)品名稱：Rabbit anti-Homo sapiens (Human) PHOX2A Polyclonal antibody
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Uniprot No.：
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基因名：PHOX2A
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別名：Aristaless homeobox (Drosophila) fibrosis of extraocular muscles congenital 2 autosomal recessive antibody; Aristaless homeobox gene homolog (Drosophila) antibody; Aristaless homeobox homolog antibody; Aristaless homeobox protein homolog antibody; ARIX 1 homeodomain protein antibody; ARIX antibody; Arix homeodomain protein antibody; ARIX1 homeodomain protein antibody; CFEOM 2 antibody; CFEOM2 antibody; FEOM 2 antibody; FEOM2 antibody; Fibrosis of extraocular muscles congenital 2 autosomal recessive antibody; MGC52227 antibody; NCAM 2 antibody; NCAM2 antibody; Paired like (aristaless) Homeobox 2A antibody; Paired like homeobox 2a antibody; Paired mesoderm homeobox 2a antibody; Paired mesoderm homeobox protein 2A antibody; Paired-like homeobox 2A antibody; PHOX 2A antibody; Phox2 antibody; Phox2a antibody; PHX2A_HUMAN antibody; Pmx 2a antibody; Pmx2 antibody; Pmx2a antibody
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宿主：Rabbit
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反應(yīng)種屬：Human
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免疫原：Recombinant Human Paired mesoderm homeobox protein 2A protein (150-264AA)
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：HRP
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA
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Protocols：
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
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靶點(diǎn)詳情
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功能：May be involved in regulating the specificity of expression of the catecholamine biosynthetic genes. Acts as a transcription activator/factor. Could maintain the noradrenergic phenotype.
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基因功能參考文獻(xiàn)：
- PHOX2A expression is finely controlled during retinoic acid differentiation and this, together with PHOX2B down-regulation. PMID: 26902400
- Genetic linkage was found at 11q13 between D11S4151 and D11S1320 and the PHOX2A gene. PMID: 22311481
- Patients with ARIX and/or PHOX2B polymorphisms had less hypoplastic superior oblique muscles. PMID: 22170461
- Mutations in the human ortholog of Aristaless cause X-linked mental retardation and epilepsy PMID: 11889467
- The paired-like homeodomain protein, Arix, mediates protein kinase A-stimulated dopamine beta-hydroxylase gene transcription through its phosphorylation status PMID: 11943777
- PHOX2A mutation analysis revealed a novel nonsense mutation in CFEOM2 (congenital fibrosis of extraocular muscles type 2) PMID: 14597037
- the polymorphisms of the ARIX gene and PHOX2B gene may be genetic risk factors for the development of congenital superior oblique muscle palsy PMID: 16049556
- PHOX2A, but not PHOX2B, seems to act directly on the c-RET promoter PMID: 16127999
- Together, these results suggest that phosphorylation of Arix by ERK1/2 inhibits its ability to interact with target genes, and that both specificity of expression and modulation by external stimuli are monitored through the same transcription factor. PMID: 16156742
- These results demonstrate the direct interactions of the Phox2a and b and dHAND transcription factors within a noradrenergic cell type PMID: 16280598
- the alpha3 subunit is expressed in every terminally differentiated ganglionic cell, this is the first example of a "pan-autonomic" gene whose expression is regulated by PHOX2 proteins. PMID: 17344216
- PHOX2A, like PHOX2B, is involved in the cascade leading to transcription factor TLX2 transactivation and presumably is involved in intestinal neuronal differentiation. PMID: 17505528
- a variant of Secretogranin II has a role in regulation by PHOX2 transcription factors and in hypertension PMID: 17584765
- The ARIX 153G>A polymorphism might be a genetic risk factor for the development of congenital superior oblique muscle palsy PMID: 18323871
- PHOX2A and PHOX2B genes are highly co-expressed in human neuroblastoma. PMID: 18949361
- PHOX2A gene, localized in a tumor suppressor candidate region at 11q, weas screened for mutations by DNA sequencing in 47 tumors of different stages. PMID: 19212675
- Transfection of Phox2a cDNA significantly increases mRNA and protein levels of norepinephrine transporter and dopamine beta-hydroxylase. PMID: 19573018
- Our 16-patient sample suggests that KIF21A and PHOX2A sequence variation does not have a role in common forms of congenital incomitant vertical strabismus. PMID: 19852579
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相關(guān)疾病：Fibrosis of extraocular muscles, congenital, 2 (CFEOM2)
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亞細(xì)胞定位：Nucleus.
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蛋白家族：Paired homeobox family
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