PHOX2A Antibody, Biotin conjugated

說明書

中文名稱：

PHOX2A兔多克隆抗體, Biotin偶聯
貨號：

CSB-PA017940LD01HU
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) PHOX2A Polyclonal antibody
Uniprot No.：

O14813
基因名：

PHOX2A
別名：

Aristaless homeobox (Drosophila) fibrosis of extraocular muscles congenital 2 autosomal recessive antibody; Aristaless homeobox gene homolog (Drosophila) antibody; Aristaless homeobox homolog antibody; Aristaless homeobox protein homolog antibody; ARIX 1 homeodomain protein antibody; ARIX antibody; Arix homeodomain protein antibody; ARIX1 homeodomain protein antibody; CFEOM 2 antibody; CFEOM2 antibody; FEOM 2 antibody; FEOM2 antibody; Fibrosis of extraocular muscles congenital 2 autosomal recessive antibody; MGC52227 antibody; NCAM 2 antibody; NCAM2 antibody; Paired like (aristaless) Homeobox 2A antibody; Paired like homeobox 2a antibody; Paired mesoderm homeobox 2a antibody; Paired mesoderm homeobox protein 2A antibody; Paired-like homeobox 2A antibody; PHOX 2A antibody; Phox2 antibody; Phox2a antibody; PHX2A_HUMAN antibody; Pmx 2a antibody; Pmx2 antibody; Pmx2a antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Paired mesoderm homeobox protein 2A protein (150-264AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Biotin
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

May be involved in regulating the specificity of expression of the catecholamine biosynthetic genes. Acts as a transcription activator/factor. Could maintain the noradrenergic phenotype.
基因功能參考文獻：
1. PHOX2A expression is finely controlled during retinoic acid differentiation and this, together with PHOX2B down-regulation. PMID: 26902400
2. Genetic linkage was found at 11q13 between D11S4151 and D11S1320 and the PHOX2A gene. PMID: 22311481
3. Patients with ARIX and/or PHOX2B polymorphisms had less hypoplastic superior oblique muscles. PMID: 22170461
4. Mutations in the human ortholog of Aristaless cause X-linked mental retardation and epilepsy PMID: 11889467
5. The paired-like homeodomain protein, Arix, mediates protein kinase A-stimulated dopamine beta-hydroxylase gene transcription through its phosphorylation status PMID: 11943777
6. PHOX2A mutation analysis revealed a novel nonsense mutation in CFEOM2 (congenital fibrosis of extraocular muscles type 2) PMID: 14597037
7. the polymorphisms of the ARIX gene and PHOX2B gene may be genetic risk factors for the development of congenital superior oblique muscle palsy PMID: 16049556
8. PHOX2A, but not PHOX2B, seems to act directly on the c-RET promoter PMID: 16127999
9. Together, these results suggest that phosphorylation of Arix by ERK1/2 inhibits its ability to interact with target genes, and that both specificity of expression and modulation by external stimuli are monitored through the same transcription factor. PMID: 16156742
10. These results demonstrate the direct interactions of the Phox2a and b and dHAND transcription factors within a noradrenergic cell type PMID: 16280598
11. the alpha3 subunit is expressed in every terminally differentiated ganglionic cell, this is the first example of a "pan-autonomic" gene whose expression is regulated by PHOX2 proteins. PMID: 17344216
12. PHOX2A, like PHOX2B, is involved in the cascade leading to transcription factor TLX2 transactivation and presumably is involved in intestinal neuronal differentiation. PMID: 17505528
13. a variant of Secretogranin II has a role in regulation by PHOX2 transcription factors and in hypertension PMID: 17584765
14. The ARIX 153G>A polymorphism might be a genetic risk factor for the development of congenital superior oblique muscle palsy PMID: 18323871
15. PHOX2A and PHOX2B genes are highly co-expressed in human neuroblastoma. PMID: 18949361
16. PHOX2A gene, localized in a tumor suppressor candidate region at 11q, weas screened for mutations by DNA sequencing in 47 tumors of different stages. PMID: 19212675
17. Transfection of Phox2a cDNA significantly increases mRNA and protein levels of norepinephrine transporter and dopamine beta-hydroxylase. PMID: 19573018
18. Our 16-patient sample suggests that KIF21A and PHOX2A sequence variation does not have a role in common forms of congenital incomitant vertical strabismus. PMID: 19852579
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相關疾病：

Fibrosis of extraocular muscles, congenital, 2 (CFEOM2)
亞細胞定位：

Nucleus.
蛋白家族：

Paired homeobox family
數據庫鏈接：

HGNC: 691

OMIM: 602078

KEGG: hsa:401

STRING: 9606.ENSP00000298231

UniGene: Hs.731115

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