PGP Antibody, FITC conjugated
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中文名稱：PGP兔多克隆抗體, FITC偶聯(lián)
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貨號：CSB-PA017873LC01HU
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規(guī)格：￥880
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其他：
產(chǎn)品詳情
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產(chǎn)品名稱：Rabbit anti-Homo sapiens (Human) PGP Polyclonal antibody
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Uniprot No.：
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基因名：PGP
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別名：PGP antibody; PGP_HUMAN antibody; PGPase antibody; Phosphoglycolate phosphatase antibody
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宿主：Rabbit
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反應(yīng)種屬：Human
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免疫原：Recombinant Human Glycerol-3-phosphate phosphatase protein (140-300AA)
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：FITC
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產(chǎn)品提供形式：Liquid
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價
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靶點詳情
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功能：Glycerol-3-phosphate phosphatase hydrolyzing glycerol-3-phosphate into glycerol. Thereby, regulates the cellular levels of glycerol-3-phosphate a metabolic intermediate of glucose, lipid and energy metabolism. Was also shown to have a 2-phosphoglycolate phosphatase activity and a tyrosine-protein phosphatase activity. However, their physiological relevance is unclear. In vitro, has also a phosphatase activity toward ADP, ATP, GDP and GTP.
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基因功能參考文獻：
- data explain how PGP exerts control over EGF-induced cellular protein tyrosine phosphorylation, and reveal an unexpected influence of triacylglycerol turnover on growth factor signaling. PMID: 29524543
- Phosphoglycolate phosphatase rescues central carbon metabolism from toxic secondary metabolites in humans and yeast. PMID: 27544441
- Data indicate that Di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) overcomes multidrug resistance (MDR) via utilization of lysosomal P-glycoprotein (Pgp) transport activity. PMID: 25720491
- acute myeloid leukemia patients with co-expression of PGP and Ly showed better overall survival compared with PGP(+) patients without Ly expression PMID: 21861206
- expressed in skin lesions from groins and axilla in patients with hidradenitis suppurativa PMID: 20091410
- The available data indicate that St. John's wort is a potent induced of CYP 3A4 and P-glycoprotein (PgP), although it may inhibit or induce other CYPs... See page 262. PMID: 15260917
- cerp-gp confers resistance to ceramide-induced apoptosis, with modulation of the ceramide-glucosylceramide pathway GCS making a marked contribution to this resistance PMID: 15661399
- the PI3K/Akt pathway is involved in MDR in lymphoma cell lines and PI3K/Akt inhibition correlates down-regulation of NF-kappaB activity and inhibition Pgp function. PMID: 18640717
- Observational study of gene-disease association. (HuGE Navigator) PMID: 16160620
- Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 17038883
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蛋白家族：HAD-like hydrolase superfamily, CbbY/CbbZ/Gph/YieH family
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組織特異性：Detected in all tissues including red cells, lymphocytes and cultured fibroblasts (at protein level). The highest activities occur in skeletal muscle and cardiac muscle.
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數(shù)據(jù)庫鏈接：
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