PGP Antibody

中文名稱：

PGP兔多克隆抗體
貨號：

CSB-PA017873LA01HU
規(guī)格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA017873LA01HU at dilution of 1:100

Immunofluorescent analysis of MCF-7 cells using CSB-PA017873LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
其他：

產品詳情
產品評價
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) PGP Polyclonal antibody
Uniprot No.：

A6NDG6
基因名：

PGP
別名：

PGP antibody; PGP_HUMAN antibody; PGPase antibody; Phosphoglycolate phosphatase antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Glycerol-3-phosphate phosphatase protein (140-300AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，PGP Antibody (CSB-PA017873LA01HU)，的標記方式是Non-conjugated。對于PGP Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA017873LB01HU	PGP Antibody, HRP conjugated	ELISA
FITC	CSB-PA017873LC01HU	PGP Antibody, FITC conjugated
Biotin	CSB-PA017873LD01HU	PGP Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Glycerol-3-phosphate phosphatase hydrolyzing glycerol-3-phosphate into glycerol. Thereby, regulates the cellular levels of glycerol-3-phosphate a metabolic intermediate of glucose, lipid and energy metabolism. Was also shown to have a 2-phosphoglycolate phosphatase activity and a tyrosine-protein phosphatase activity. However, their physiological relevance is unclear. In vitro, has also a phosphatase activity toward ADP, ATP, GDP and GTP.
基因功能參考文獻：
1. data explain how PGP exerts control over EGF-induced cellular protein tyrosine phosphorylation, and reveal an unexpected influence of triacylglycerol turnover on growth factor signaling. PMID: 29524543
2. Phosphoglycolate phosphatase rescues central carbon metabolism from toxic secondary metabolites in humans and yeast. PMID: 27544441
3. Data indicate that Di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) overcomes multidrug resistance (MDR) via utilization of lysosomal P-glycoprotein (Pgp) transport activity. PMID: 25720491
4. acute myeloid leukemia patients with co-expression of PGP and Ly showed better overall survival compared with PGP(+) patients without Ly expression PMID: 21861206
5. expressed in skin lesions from groins and axilla in patients with hidradenitis suppurativa PMID: 20091410
6. The available data indicate that St. John's wort is a potent induced of CYP 3A4 and P-glycoprotein (PgP), although it may inhibit or induce other CYPs... See page 262. PMID: 15260917
7. cerp-gp confers resistance to ceramide-induced apoptosis, with modulation of the ceramide-glucosylceramide pathway GCS making a marked contribution to this resistance PMID: 15661399
8. the PI3K/Akt pathway is involved in MDR in lymphoma cell lines and PI3K/Akt inhibition correlates down-regulation of NF-kappaB activity and inhibition Pgp function. PMID: 18640717
9. Observational study of gene-disease association. (HuGE Navigator) PMID: 16160620
10. Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 17038883
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蛋白家族：

HAD-like hydrolase superfamily, CbbY/CbbZ/Gph/YieH family
組織特異性：

Detected in all tissues including red cells, lymphocytes and cultured fibroblasts (at protein level). The highest activities occur in skeletal muscle and cardiac muscle.
數據庫鏈接：

HGNC: 8909

OMIM: 172280

KEGG: hsa:283871

STRING: 9606.ENSP00000330918

UniGene: Hs.442634

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