PDGFD Antibody
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中文名稱：PDGFD兔多克隆抗體
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貨號：CSB-PA887935ESR2HU
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規格：￥440
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圖片：
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Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA887935ESR2HU at dilution of 1:100 -
Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA887935ESR2HU at dilution of 1:100
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) PDGFD Polyclonal antibody
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Uniprot No.：
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基因名：
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別名：IEGF antibody; Iris expressed growth factor antibody; Iris-expressed growth factor antibody; MGC26867 antibody; MSTP036 antibody; PDGF D antibody; PDGF-D antibody; PDGFD antibody; PDGFD latent form antibody; PDGFD receptor-binding form antibody; PDGFD_HUMAN antibody; Platelet derived growth factor D antibody; Platelet-derived growth factor D antibody; receptor-binding form antibody; rSCDGF-B antibody; SCDGF B antibody; SCDGF-B antibody; SCDGFB antibody; Spinal cord derived growth factor B antibody; Spinal cord-derived growth factor B antibody; spinal-cord derived growth factor-B protein antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Platelet-derived growth factor D protein (191-370AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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產品提供形式：Liquid
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應用范圍：ELISA, IHC
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推薦稀釋比：
Application Recommended Dilution IHC 1:20-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an important role in wound healing. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. Can initiate events that lead to a mesangial proliferative glomerulonephritis, including influx of monocytes and macrophages and production of extracellular matrix.
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基因功能參考文獻：
- PDGF-D promotes tumor growth and aggressiveness of colorectal carcinoma. Down-regulation of PDGF-D inactivates Notch1/Twist1 axis, which could reverse epithelial mesenchymal transformation and prevent CRC progression. PMID: 28035069
- significant correlations between DNA methylation of the PDGFD gene promoter and the risk of developing either IA or BAVM PMID: 28346846
- This study suggested that epithelial-mesenchymal transition process can be triggered by the PDGF-D/PDGFRb axis in tongue squamous cell carcinoma, and then involved in the tumor cell invasion via activation of p38/AKT/ERK/ epithelial-mesenchymal transition pathway. PMID: 27507215
- No specific genotype of rs974819 of Platelet-derived growth factor D demonstrated increased cardiovascular mortality in the total population, however, the male group with genotypes A/A and G/A demonstrated an increased risk that persisted in a multivariate evaluation where adjustments were made for well-known cardiovascular risk factors. PMID: 27585990
- upregulated in kidney fibrosis, may mediate renal scarring, and is dispensable for normal kidney development and physiological functions PMID: 26924050
- polymorphism of rs7950273 in the PDGFD gene is not associated with ischaemic stroke in the Chinese Han population PMID: 26362023
- Novel findings reveal a new paradigm in matriptase activation involving PDGF-D-specific signal transduction leading to extracellular acidosis. PMID: 26157007
- PDGF-D expression is associated with miR-106a and Twist1 in HCC patients PMID: 25760076
- PDGF-D is highly expressed by ASCs, where it acts as a potent mitogenic factor. PMID: 25332166
- PDGFD, CDH1 and SLIT2 are upregulated in low grade meningiomas and schwannomas compared with healthy tissue. PMID: 25333347
- PDGF-DD secreted by gastric cancer derived mesenchymal stem cells is capable of promoting gastric cancer cell progression in vitro and in vivo. PMID: 24938433
- Data suggest that targeting platelet-derived growth factor-D as a strategy for endometrial cancer treatment. PMID: 24646915
- Compared with matched normal endometrial cases, PDGF-D was up-regulated in endometrial cancer. Expression of PDGF-D protein, found in 78% of the cases, was associated with nonendometrioid histologic type. PMID: 24870786
- PDGFD-PDGFRbeta signalling is required for human neocortical development and local production of growth factors by radial glia supports the expanded germinal region and progenitor heterogeneity of species with large brains PMID: 25391964
- PDGF-D is highly expressed in gemcitabine resistant (GR) liver neoplasm cells. Furthermore, down-regulation of PDGF-D in GR cells led to partial reversal of the EMT phenotype. PMID: 24158561
- Down-regulation of platelet-derived growth factor-D expression blockades NF-kappaB pathway to inhibit cell proliferation and invasion as well as induce apoptosis in esophageal squamous cell carcinoma. PMID: 23187740
- Platelet-derived growth factor-D and Rho GTPases regulate recruitment of cancer-associated fibroblasts in cholangiocarcinoma. PMID: 23505219
- Taken together with our previous finding that matriptase is a proteolytic activator of PDGF D, this study provides a molecular insight into signal amplification of the proteolytic network and PDGF signaling loop during cancer progression. PMID: 22689130
- Meta-analysis showed that single nucleotide polymorphism rs974819 of PDGFD gene was significantly associated with an increasing risk of coronary heart disease (OR=1.08, 95% CI=1.05 - 1.11) in both Europeans and South Asians including Han Chinese. PMID: 22704460
- High PDGFD expression promotes ovarian cancer invasion by regulating matrix metalloproteinases 2 and 9 PMID: 22471482
- PDGF-D promotes malignant mesothelioma cell chemotaxis through PDGF-betabeta receptor signaling pathways along a PI3 kinase/PDK1/Akt/Rac1/ROCK axis and relevant to ERK activation PMID: 22415093
- The results of this study suggested that PDGFD -858A/C variant is probably associated with risk for non-hypertensive intracerebral hemorrhage. PMID: 22289441
- Study unveiled a novel signaling axis of matriptase/PDGF-D/beta-PDGFR in PCa, providing new insights into functional interplay between serine protease and growth factor signaling networks. PMID: 21098708
- human umbilical cord blood tropism toward glioma cells are partially dependent on the PDGF/PGGFR system. PMID: 20406896
- Compared with control group, levels of PDGF-D and PDGF-B were progressively elevated in blood and urine of IgA nephropathy children. PMID: 18471357
- LH significantly increased PDGF-D messenger RNA (mRNA) expression but suppressed PDGF-B and PDGF-C mRNA in human granulosa-luteal cells PMID: 19733850
- PDGF-D-induced acquisition of the EMT phenotype in PC3 cells is, in part, a result of repression of miR-200. PMID: 19544444
- Platelet-derived growth factor D: tumorigenicity in mice and dysregulated expression in human cancer PMID: 11980634
- we localized PDGF-D in human kidneys suggesting that PDGF-D may have a role in kidney development. PMID: 12427128
- PDGF-D plays an important role in the pathogenesis of tubulointerstitial injury through binding of PDGF-Rbeta in both human obstructive nephropathy PMID: 14514732
- full-length PDGF-D is activated in tissues and is capable of increasing interstitial fluid pressure and macrophage recruitment and the maturation of blood vessels in angiogenic processes. PMID: 15271796
- PDGF D is activated and processed by urokinase plasminogen activator and they colocalize in human prostate carcinoma. PMID: 15988036
- Sp1, like Ets-1, induces PDGF-D transcription and mRNA expression; H2O2 stimulates Ets-1, but not Sp1, and activates D3-dependent PDGF-D transcription PMID: 16189269
- PDGF-D is present in the neointima of the arteriopathy of Chronic allograft nephropathy, where it can engage PDGF-Rbeta to promote mesenchymal cell migration, proliferation, and neointima formation. PMID: 18187181
- All 3 residues in Sp1 (Thr668, Ser670, and Thr681) are required for Sp1-dependent platelet-derived growth factor-D activation in response to angiotensin II PMID: 18258854
- PDGF-D promotes epithelial-mesenchymal transitiion and thus could be a novel therapeutic target for the prevention and/or treatment of prostate cancer. PMID: 18403754
- Association of platelet-derived growth factor-D gene polymorphism with ischemic stroke in a Chinese case-control study PMID: 18600092
- uPA not only generates active PDGF-DD, but also regulates its spatial distribution, provides novel insights into the biological function of PDGF-DD. PMID: 18997817
- PDGF-DD, a novel mediator of smooth muscle cell phenotypic modulation, is upregulated in endothelial cells exposed to atherosclerosis-prone flow patterns. PMID: 19028801
- PDGF-DD serum levels in patients with IgA nephropathy (IgAN) were significantly higher (1.67 +/- 0.45 ng/ml) and in patients with lupus nephritis significantly lower (0.66 +/- 0.86 ng/ml) compared to healthy controls. PMID: 19357108
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亞細胞定位：Secreted. Note=Released by platelets upon wounding.
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蛋白家族：PDGF/VEGF growth factor family
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組織特異性：Expressed at high levels in the heart, pancreas, adrenal gland and ovary and at low levels in placenta, liver, kidney, prostate, testis, small intestine, spleen and colon. In the kidney, expressed by the visceral epithelial cells of the glomeruli. A wides
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