PAX1 Antibody

說明書

中文名稱：

PAX1兔多克隆抗體
貨號：

CSB-PA020238
規格：

￥1090
圖片：
Western Blot analysis of 293T cells using Pax-1 Polyclonal Antibody
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

P15863
基因名：

PAX1
別名：

HUP48 antibody; OTTHUMP00000030407 antibody; Paired box 1 antibody; Paired box gene 1 antibody; Paired box protein Pax 1 antibody; Paired box protein Pax-1 antibody; Paired domain gene HuP48 antibody; PAX 1 antibody; Pax1 antibody; PAX1_HUMAN antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Synthesized peptide derived from the Internal region of Human Pax-1.
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

WB, IHC, ELISA

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:100-1:300
ELISA	1:5000

Protocols：

Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

This protein is a transcriptional activator. It may play a role in the formation of segmented structures of the embryo. May play an important role in the normal development of the vertebral column.
基因功能參考文獻：
1. The association between PAX1 and the susceptibility of AIS was successfully replicated in the Chinese population PMID: 29095406
2. Hypermethylated ZNF582 and PAX1 genes in the oral scrapings collected from adjacent normal oral mucosal sites rather than cancer sites are associated with aggressive progression and poor prognosis of OSCC PMID: 29224816
3. A novel PAX1 null homozygous mutation in autosomal recessive otofaciocervical syndrome associated with severe combined immunodeficiency has been described in a consanguineous family. PMID: 28657137
4. PAX1 gene methylation was associated with the transition of CIN I to CIN II/III and CIN II/III to cervical cancer, so that it could be an auxiliary biomarker to estimate the risk of CIN progress. PMID: 28472814
5. conclude that hypermethylated ZNF582 and PAX1 are effective biomarkers for the detection of oral dysplasia and oral cancer and for the prediction of oral cancer recurrence PMID: 27865370
6. DNA methylation status of PAX1 showed a relatively good sensitivity and specificity for the detection of ESOPHAGEAL SQUAMOUS CELL CARCINOMA. PMID: 28241446
7. Paired boxed gene 1 protein expression is a potential histopathology biomarker for the differential diagnosis of malignant and premalignant endometrial lesions. Paired boxed gene 1 is also a potential prognostic marker in cases of endometrial carcinoma. PMID: 27226215
8. Hypermethylation of PAX1 gene may be highly associated with the development of cervical cancer. PMID: 26552048
9. meta-analysis support the utility of PAX1 methylation as an auxiliary biomarker in cervical cancer screening PMID: 26234429
10. Testing PAX1 DNA methylation using oral swabs is a promising method for oral cancer detection. Combined assessments regarding betel nut consumption and DNA methylation can improve OSCC screening PMID: 23907469
11. PAX1 methylation hallmarks a potential diagnostic value for cervical cancer screening in Asians PMID: 26642709
12. analysis of a PAX1 enhancer locus that is associated with susceptibility to idiopathic scoliosis in females PMID: 25784220
13. PAX1 and SOX1 DNA methylation correlate with a cervical intraepithelial neoplasia diagnosis. PMID: 24799352
14. PAX1 methylation is associated with cervical cancer. PMID: 24844223
15. PAX1 methylation is associated with high-grade squamous intraepithelial lesions. PMID: 24568514
16. Cervical adenocarcinoma cells carry aberrantly high methylation rates of PAX1, commonly methylated in squamous cell carcinomas. PMID: 24407576
17. We identified PAX1 as a novel disease-causing gene for otofaciocervical syndrome and show that the pooling of DNA from affected individuals can reduce the number of putative disease-causing homozygous variants in consanguineous families. PMID: 23851939
18. PAX1 hypermethylation is associated with cervical cancer. PMID: 20442585
19. There was a significant reduction in PAX1 expression in fetuses with the Jarcho-Levin syndrome. PMID: 12833407
20. No mutations were identified in the PAX1 and MEOX1 exons or flanking intronic sequences, excluding them as likely causative genes for diaphanospondylodysostosis PMID: 17764081
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相關疾病：

Otofaciocervical syndrome 2 (OTFCS2)
亞細胞定位：

Nucleus.
數據庫鏈接：

HGNC: 8615

OMIM: 167411

KEGG: hsa:5075

STRING: 9606.ENSP00000381499

UniGene: Hs.122310

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