PAFAH1B2 Antibody

中文名稱：

PAFAH1B2兔多克隆抗體
貨號：

CSB-PA017384LA01HU
規(guī)格：

￥440
圖片：
Immunofluorescent analysis of MCF-7 cells using CSB-PA017384LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

Immunohistochemistry analysis of human colon cancer using CSB-PA017384LA01HU at dilution of 1:100

Immunohistochemistry analysis of human glioma using CSB-PA017384LA01HU at dilution of 1:100
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) PAFAH1B2 Polyclonal antibody
Uniprot No.：

P68402
基因名：

PAFAH1B2
別名：

Intracellular platelet activating factor acetylhydrolase alpha 2 subunit antibody; PA1B2_HUMAN antibody; PAF acetylhydrolase 30 kDa subunit antibody; PAF AH 30 kDa subunit antibody; PAF AH beta subunit antibody; PAF AH subunit beta antibody; PAF-AH 30 kDa subunit antibody; PAF-AH subunit beta antibody; PAFAH 30 kDa subunit antibody; PAFAH beta subunit antibody; PAFAH subunit beta antibody; Pafah1b2 antibody; PAFAH1B2 protein antibody; PAFAHB antibody; Platelet activating factor acetylhydrolase 1b catalytic subunit 2 antibody; Platelet activating factor acetylhydrolase IB beta subunit antibody; Platelet activating factor acetylhydrolase IB subunit beta antibody; Platelet activating factor acetylhydrolase isoform Ib beta subunit antibody; Platelet activating factor acetylhydrolase isoform Ib subunit 2 antibody; Platelet-activating factor acetylhydrolase IB subunit beta antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human Platelet-activating factor acetylhydrolase IB subunit beta protein (2-229AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產(chǎn)品，PAFAH1B2 Antibody (CSB-PA017384LA01HU)，的標記方式是Non-conjugated。對于PAFAH1B2 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產(chǎn)品名稱	應(yīng)用
HRP	CSB-PA017384LB01HU	PAFAH1B2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA017384LC01HU	PAFAH1B2 Antibody, FITC conjugated
Biotin	CSB-PA017384LD01HU	PAFAH1B2 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

Alpha2 catalytic subunit of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)) heterotetrameric enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and modulates the action of PAF. The activity and substrate specificity of PAF-AH (I) are affected by its subunit composition. The alpha2/alpha2 homodimer (PAFAH1B2/PAFAH1B2 homodimer) hydrolyzes PAF and 1-O-alkyl-2-acetyl-sn-glycero-3-phosphorylethanolamine (AAGPE) more efficiently than 1-O-alkyl-2-acetyl-sn-glycero-3-phosphoric acid (AAGPA). In contrast, the alpha1/alpha2 heterodimer(PAFAH1B3/PAFAH1B3 heterodimer) hydrolyzes AAGPA more efficiently than PAF, but has little hydrolytic activity towards AAGPE. May play a role in male germ cell meiosis during the late pachytenestage and meiotic divisions as well as early spermiogenesis.
基因功能參考文獻：
1. PAF is demonstrated to be the key indicator in the lipid metabolism of polypoidal choroidal vasculopathy patients in this study. PMID: 27910906
2. PAFAH1B2 and 1B3 are important in maintaining cancer pathogenicity across a wide spectrum of cancer types. PMID: 25945974
3. The R92H and I198T polymorphisms are highly related to the plasma PAF-AH levels and the risk of coronary heart disease, especially among patients with blood stasis syndrome. PMID: 25034894
4. aspirin is hydrolyzed in plasma by two enzymes, BChE and a new extracellular form of platelet-activating factor acetylhydrolase, PAFAH1b2. PMID: 23508960
5. Knockdown of PAFAH1B2 strongly reduced Abeta secretion from human cells, and this effect was confirmed in primary cells derived from PAFAH1B2 knock-out mice PMID: 23238734
6. Plasma PAF-AH can hydrolyze oxidized phospholipids, and may attenuate the spreading of lipid peroxidation and participate in defense mechanisms against vasospasm after aneurysmal subarachnoid hemorrhage. PMID: 21866060
7. intracellular type I PAF acetylhydrolase (PAFAH1B2 and PAFAH1B3) is the major aspirin hydrolase of human blood PMID: 21844189
8. PAFAH1B2 is not the gene responsible for the linkage evidence on chromosome 11q23 in protein C deficiency. PMID: 17849047
9. splice variants of the Pafah1b2 gene transcript retain exons 1-5 and replace exon 6 with alternative exons derived from genomic sequence 3' to exon 6. Splice variants encode two proteins with different novel carboxy termini PMID: 18155631
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亞細胞定位：

Cytoplasm.
蛋白家族：

'GDSL' lipolytic enzyme family, Platelet-activating factor acetylhydrolase IB beta/gamma subunits subfamily
組織特異性：

Ubiquitous.
數(shù)據(jù)庫鏈接：

HGNC: 8575

OMIM: 602508

KEGG: hsa:5049

STRING: 9606.ENSP00000435289

UniGene: Hs.728488

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