PADI1 Antibody, FITC conjugated

說明書

中文名稱：

PADI1兔多克隆抗體, FITC偶聯
貨號：

CSB-PA891543LC01HU
規格：

￥880
其他：

產品詳情
產品評價
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) PADI1 Polyclonal antibody
Uniprot No.：

Q9ULC6
基因名：

PADI1
別名：

HPAD10 antibody; Padi1 antibody; PADI1_HUMAN antibody; PDI antibody; PDI1 antibody; Peptidylarginine deiminase I antibody; protein arginine deiminase type I antibody; Protein-arginine deiminase type I antibody; Protein-arginine deiminase type-1 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Protein-arginine deiminase type-1 protein (1-663AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

FITC
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Catalyzes the deimination of arginine residues of proteins.
基因功能參考文獻：
1. Authors showed that PAD1 interacts with and citrullinates MEK1 thereby disrupting MEK1-catalyzed ERK1/2 phosphorylation, thus leading to the MMP2 overexpression. PMID: 28844713
2. Identify acefylline as an activator of peptidylarginine deiminase 1 and 3 in the epidermis, resulting in filaggrin deimination. PMID: 26616205
3. NF-kappaB-mediated signaling pathway is involved in PADI1 regulation in human epidermal keratinocytes PMID: 20596086
4. cloning, gene organization, and expression analysis PMID: 12416996
5. peptidylarginine deiminase types 1 and 3 loci map to chromosomal band 1p36.13 PMID: 15150696
6. PAD1 and 3 are able to modify filaggrin PMID: 15675958
7. PAD1 is co-located with filaggrin within the filamentous matrix of the deeper corneocytes where the protein is deiminated. PMID: 16091842
8. MZF1 and Sp1/Sp3 binding to the promoter region drive the PADI1 expression in keratinocytes PMID: 17851584
9. The expressoin of COL1A1-PADI1 genes were particularly effective in distinguishing OCSS from normal tissue. PMID: 18669583
10. peptidylarginine deiminase citrullinates the chemokine CXCL8, and thus may dampen neutrophil extravasation during acute or chronic inflammation PMID: 18710930
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亞細胞定位：

Cytoplasm.
蛋白家族：

Protein arginine deiminase family
組織特異性：

Detected in epidermal keratinocytes (at protein level). Epidermis, prostate, testis, placenta, spleen and thymus.
數據庫鏈接：

HGNC: 18367

OMIM: 607934

KEGG: hsa:29943

STRING: 9606.ENSP00000364620

UniGene: Hs.412941

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