OXCT1 Antibody

說明書

中文名稱：

OXCT1兔多克隆抗體
貨號：

CSB-PA017306ESR2HU
規格：

￥440
圖片：
Western blot
All lanes: OXCT1 antibody at 8μg/ml
Lane 1: Mouse heart tissue
Lane 2: Mouse kidney tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 57, 14 kDa
Observed band size: 57 kDa

Immunohistochemistry of paraffin-embedded human heart tissue using CSB-PA017306ESR2HU at dilution of 1:100
其他：

產品詳情
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) OXCT1 Polyclonal antibody
Uniprot No.：

P55809
基因名：

OXCT1
別名：

3 oxoacid CoA transferase 1 antibody; 3-oxoacid CoA-transferase 1 antibody; EC 2.8.3.5 antibody; OTTHUMP00000120012 antibody; OTTHUMP00000221550 antibody; OXCT antibody; Oxct1 antibody; SCOT antibody; Scot S antibody; Scot-S antibody; SCOT1_HUMAN antibody; Somatic type succinyl CoA:3 oxoacid CoA transferase antibody; Somatic-type succinyl-CoA:3-oxoacid CoA-transferase antibody; Succinyl CoA:3 ketoacid CoA transferase antibody; Succinyl CoA:3 ketoacid coenzyme A transferase 1 mitochondrial antibody; Succinyl CoA:3 oxoacid CoA transferase antibody; Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial antibody
宿主：

Rabbit
反應種屬：

Human, Mouse
免疫原：

Recombinant Human Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial protein (261-520AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:20-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.
基因功能參考文獻：
1. Crystal structure of human SCOT, providing a molecular understanding of the reported mutations based on their potential structural effects. PMID: 23420214
2. Case Report: Succinyl-CoA:3-ketoacid CoA transferase (SCOT) deficiency causes episodic ketoacidotic crises and no apparent symptoms between them. PMID: 20652411
3. Data show that the ketone body metabolizing enzymes BDH1, BDH2, OXCT1 and ACAT1 were expressed at the mRNA and protein level in all glioma cell lines. PMID: 21791085
4. Missense Mutations in succinyl-CoA:3-ketoacid CoA transferase is associated with Ketoacidosis. PMID: 21296660
5. Results demonstrate that h-Scot-t is a single intronless gene specifically expressed in the testis. PMID: 11756565
6. In SCOT-deficient patients retaining some residual activity, permanent ketosis may be absent. PMID: 15496607
7. A 6-bp deletion at the splice donor site of intron 1 resulted in the absence of a full-length mature SCOT mRNA with faint amounts of aberrantly spliced transcripts using a cryptic splice donor site within exon 1. PMID: 16765626
8. the R268H mutation is a ketoacidosis-causing one PMID: 17706444
9. liver-specific silencing of the SCOT gene expression may be mediated in part by its 5'-flanking sequence PMID: 18648183
10. The activities of pyruvate carboxylase (SCOT) were decreased by 65% in pancreatic islets of patients with type 2 diabetes. PMID: 19296078
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相關疾病：

Succinyl-CoA:3-oxoacid CoA transferase deficiency (SCOTD)
亞細胞定位：

Mitochondrion matrix.
蛋白家族：

3-oxoacid CoA-transferase family
組織特異性：

Abundant in heart, followed in order by kidney, brain, and muscle, whereas in liver it is undetectable; also detectable in leukocytes and fibroblasts.
數據庫鏈接：

HGNC: 8527

OMIM: 245050

KEGG: hsa:5019

STRING: 9606.ENSP00000196371

UniGene: Hs.278277

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