OXCT1 Antibody
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中文名稱：OXCT1兔多克隆抗體
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貨號：CSB-PA017306GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：
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別名：3 oxoacid CoA transferase 1 antibody; 3-oxoacid CoA-transferase 1 antibody; EC 2.8.3.5 antibody; OTTHUMP00000120012 antibody; OTTHUMP00000221550 antibody; OXCT antibody; Oxct1 antibody; SCOT antibody; Scot S antibody; Scot-S antibody; SCOT1_HUMAN antibody; Somatic type succinyl CoA:3 oxoacid CoA transferase antibody; Somatic-type succinyl-CoA:3-oxoacid CoA-transferase antibody; Succinyl CoA:3 ketoacid CoA transferase antibody; Succinyl CoA:3 ketoacid coenzyme A transferase 1 mitochondrial antibody; Succinyl CoA:3 oxoacid CoA transferase antibody; Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Human SCOT
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,WB,IHC,IF
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.
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基因功能參考文獻：
- Crystal structure of human SCOT, providing a molecular understanding of the reported mutations based on their potential structural effects. PMID: 23420214
- Case Report: Succinyl-CoA:3-ketoacid CoA transferase (SCOT) deficiency causes episodic ketoacidotic crises and no apparent symptoms between them. PMID: 20652411
- Data show that the ketone body metabolizing enzymes BDH1, BDH2, OXCT1 and ACAT1 were expressed at the mRNA and protein level in all glioma cell lines. PMID: 21791085
- Missense Mutations in succinyl-CoA:3-ketoacid CoA transferase is associated with Ketoacidosis. PMID: 21296660
- Results demonstrate that h-Scot-t is a single intronless gene specifically expressed in the testis. PMID: 11756565
- In SCOT-deficient patients retaining some residual activity, permanent ketosis may be absent. PMID: 15496607
- A 6-bp deletion at the splice donor site of intron 1 resulted in the absence of a full-length mature SCOT mRNA with faint amounts of aberrantly spliced transcripts using a cryptic splice donor site within exon 1. PMID: 16765626
- the R268H mutation is a ketoacidosis-causing one PMID: 17706444
- liver-specific silencing of the SCOT gene expression may be mediated in part by its 5'-flanking sequence PMID: 18648183
- The activities of pyruvate carboxylase (SCOT) were decreased by 65% in pancreatic islets of patients with type 2 diabetes. PMID: 19296078
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相關疾病：Succinyl-CoA:3-oxoacid CoA transferase deficiency (SCOTD)
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亞細胞定位：Mitochondrion matrix.
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蛋白家族：3-oxoacid CoA-transferase family
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組織特異性：Abundant in heart, followed in order by kidney, brain, and muscle, whereas in liver it is undetectable; also detectable in leukocytes and fibroblasts.
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數據庫鏈接：
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