ORC2 Antibody
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中文名稱：ORC2兔多克隆抗體
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貨號：CSB-PA017232GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：
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別名：orc2 antibody; ORC2_HUMAN antibody; ORC2L antibody; Origin of replication 2 (yeast homolog) like antibody; Origin recognition complex protein 2 homolog antibody; Origin recognition complex subunit 2 antibody; Origin recognition complex subunit 2 isoform B antibody; Origin recognition complex subunit 2 like (yeast) antibody; Origin recognition complex, subunit 2 homolog antibody; Origin recognition complex, subunit 2, S. cerevisiae, homolog of antibody; Origin recognition complex, subunit 2-like (S. cerevisiae) antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Human ORC2L
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,WB
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3. Stabilizes LRWD1, by protecting it from ubiquitin-mediated proteasomal degradation. Also stabilizes ORC3.
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基因功能參考文獻：
- the ORC2 complex with E2 restricts viral replication in the maintenance phase of the viral replication program PMID: 27701460
- ORC2 SUMOylation promotes recruitment of KDM5A to centromeres. PMID: 27052177
- Protein phosphatase 1 dephosphorylates Orc2 to promote the binding of ORC to chromatin and replication origins for the subsequent round of the cell cycle. PMID: 24792176
- These results suggest that PP1 dephosphorylates Orc2 to promote the binding of ORC to chromatin. PMID: 24732362
- Gemcitabine resistance is dependent on Plk1-mediated phosphorylation of Orc2 and Hbo1. PMID: 23188630
- Orc2 protects ORCA from ubiquitin-mediated degradation in vivo. PMID: 22935713
- The phosphorylation of ORC2 dissociates origin recognition complex (ORC) from chromatin and replication origins and inhibits binding of ORC to newly replicated DNA. PMID: 22334659
- Plk1 phosphorylation of Orc2 promotes DNA replication under conditions of stress PMID: 21947279
- the human origin recognition complex has a role in sequence-independent DNA binding and replication initiation PMID: 12897055
- The precise nucleotide of binding for ORC2 was identified near the stgart site for leading-strand synthesis; the transition to the post-replicative complex is accompanied by a 17 bp displacement of ORC2 towards the start site. PMID: 12912926
- Study using HCT116 haplo-insufficient cells and Orc2 hypomorphic cells demonstrates that human Ku80 and Orc2 bind to replication origins independently of each other. PMID: 15910003
- The low level of Orc2 in Orc2 hypomorphic cells hinders normal cell cycle progression by delaying the activation of G1 cyclin-dependent kinases. PMID: 16407251
- human Orc2 has specific domains that are required in vivo for assembly and nuclear localization of the origin recognition complex PMID: 16762929
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亞細胞定位：Nucleus.
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蛋白家族：ORC2 family
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數據庫鏈接：
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