NOP10 Antibody, Biotin conjugated

文獻引用 (1) 說明書

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) NOP10 Polyclonal antibody
Uniprot No.：

Q9NPE3
基因名：

NOP10
別名：

DKCB1 antibody; H/ACA ribonucleoprotein complex subunit 3 antibody; homolog of yeast Nop10p antibody; MGC70651 antibody; NOLA3 antibody; NOP10 antibody; NOP10 ribonucleoprotein homolog (yeast) antibody; NOP10_HUMAN antibody; NOP10P antibody; Nucleolar protein 10 antibody; Nucleolar protein family A member 3 antibody; nucleolar protein family A, member 3 (H/ACA small nucleolar RNPs) antibody; snoRNP protein NOP10 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human H/ACA ribonucleoprotein complex subunit 3 protein (1-64AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Biotin
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme.
基因功能參考文獻：
1. Indian aplastic anemia patients did not have NOP10 mutations. PMID: 25906515
2. Effects of dyskeratosis congenita mutations in NOP10 on assembly of H/ACA pre-RNPs PMID: 20008900
3. NOP10 has a role in the telomerase complex and telomere maintenance, and in autosomal recessive dyskeratosis congenita PMID: 17507419
相關疾病：

Dyskeratosis congenita, autosomal recessive, 1 (DKCB1)
亞細胞定位：

Nucleus, nucleolus. Nucleus, Cajal body. Note=Also localized to Cajal bodies (coiled bodies).
蛋白家族：

NOP10 family
數據庫鏈接：

HGNC: 14378

OMIM: 224230

KEGG: hsa:55505

STRING: 9606.ENSP00000332198

UniGene: Hs.14317

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