NFYB Antibody

說明書

中文名稱：

NFYB兔多克隆抗體
貨號：

CSB-PA015774ESR2HU
規格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA015774ESR2HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human thymus tissue using CSB-PA015774ESR2HU at dilution of 1:100
其他：

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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) NFYB Polyclonal antibody
Uniprot No.：

P25208
基因名：

NFYB
別名：

CAAT box DNA binding protein subunit B antibody; CAAT box DNA-binding protein subunit B antibody; CBF A antibody; CBF B antibody; CCAAT binding transcription factor subunit A antibody; HAP 3 antibody; HAP3 antibody; NF Y protein chain B antibody; NF YB antibody; NF-YB antibody; NFYB antibody; NFYB_HUMAN antibody; Nuclear transcription factor Y beta antibody; Nuclear transcription factor Y subunit B antibody; Nuclear transcription factor Y subunit beta antibody; Transcription factor NF Y B subunit antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Nuclear transcription factor Y subunit beta protein (1-207AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.
基因功能參考文獻：
1. The nuclear transcription factor Y subunit beta (NFYB)-E2F transcription factor 1 (E2F1) pathway displays a crucial role in the chemoresistance ofoxaliplatin-resistant colorectal cancer (OR-CRC) by inducing the expression and activation of checkpoint kinase 1 (CHK1), suggesting a possible therapeutic target for oxaliplatin resistance in CRC. PMID: 29203250
2. NF-YB transcription factor was identified as a novel direct E2F1 target. PMID: 26039627
3. The NF-Y complex is asymmetric, with NF-YB binding approximately 15 bp downstream from the CCAAT motif. PMID: 23595228
4. Transcriptional repression mediated by IER5 regulates Cdc25B expression levels via the release of NF-YB and p300 in acute myeloid leukemia. PMID: 22132193
5. NF-Y acts upstream of H3K4me3 deposition by recruiting Ash2L PMID: 21445285
6. MicroRNA-485-3p regulates drug responsiveness by decreasing nuclear factor-YB expression, which in turn negatively regulates DNA topoisomerase IIalpha. PMID: 21252292
7. The NF-YB/NF-YC structure gives insight into DNA binding and transcription regulation by CCAAT factor NF-Y. PMID: 12401788
8. CBF/NF-Y proteins regulate the transcription of COL11A1 by directly binding to the ATTGG sequence in the proximal promoter region PMID: 12805369
9. Co-operative functional interactions between Sp1 & NF-Y are required to direct the activity of the ATP1A3 promoter predominantly in neuronal cells. PMID: 15462673
10. trichostatin A activates the transcription of TSP1 gene through the binding of transcription factor CBF to CCAAT box and the enhanced histone acetylation. PMID: 18275041
11. CBF-A is a novel transacting factor required for cytoplasmic mRNA transport and localization PMID: 18480411
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亞細胞定位：

Nucleus.
蛋白家族：

NFYB/HAP3 subunit family
數據庫鏈接：

HGNC: 7805

OMIM: 189904

KEGG: hsa:4801

STRING: 9606.ENSP00000240055

UniGene: Hs.84928

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