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中文名稱：NFYB兔多克隆抗體
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貨號：CSB-PA003425
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規格：￥1090
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圖片：
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Western Blot analysis of 293 cells using NF-YB Polyclonal Antibody
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其他：
產品詳情
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Uniprot No.：
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基因名：
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別名：CAAT box DNA binding protein subunit B antibody; CAAT box DNA-binding protein subunit B antibody; CBF A antibody; CBF B antibody; CCAAT binding transcription factor subunit A antibody; HAP 3 antibody; HAP3 antibody; NF Y protein chain B antibody; NF YB antibody; NF-YB antibody; NFYB antibody; NFYB_HUMAN antibody; Nuclear transcription factor Y beta antibody; Nuclear transcription factor Y subunit B antibody; Nuclear transcription factor Y subunit beta antibody; Transcription factor NF Y B subunit antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Synthesized peptide derived from the N-terminal region of Human NF-YB.
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產品提供形式：Liquid
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應用范圍：WB, IHC, ELISA
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 IHC 1:100-1:300 ELISA 1:10000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
引用文獻
- Coptisine-mediated downregulation of E2F7 induces G2/M phase arrest in hepatocellular carcinoma cells through inhibition of E2F4/NFYA/NFYB transcription factors H Wang,Chemico-biological interactions,2024
產品評價
相關產品
靶點詳情
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功能：Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.
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基因功能參考文獻：
- The nuclear transcription factor Y subunit beta (NFYB)-E2F transcription factor 1 (E2F1) pathway displays a crucial role in the chemoresistance ofoxaliplatin-resistant colorectal cancer (OR-CRC) by inducing the expression and activation of checkpoint kinase 1 (CHK1), suggesting a possible therapeutic target for oxaliplatin resistance in CRC. PMID: 29203250
- NF-YB transcription factor was identified as a novel direct E2F1 target. PMID: 26039627
- The NF-Y complex is asymmetric, with NF-YB binding approximately 15 bp downstream from the CCAAT motif. PMID: 23595228
- Transcriptional repression mediated by IER5 regulates Cdc25B expression levels via the release of NF-YB and p300 in acute myeloid leukemia. PMID: 22132193
- NF-Y acts upstream of H3K4me3 deposition by recruiting Ash2L PMID: 21445285
- MicroRNA-485-3p regulates drug responsiveness by decreasing nuclear factor-YB expression, which in turn negatively regulates DNA topoisomerase IIalpha. PMID: 21252292
- The NF-YB/NF-YC structure gives insight into DNA binding and transcription regulation by CCAAT factor NF-Y. PMID: 12401788
- CBF/NF-Y proteins regulate the transcription of COL11A1 by directly binding to the ATTGG sequence in the proximal promoter region PMID: 12805369
- Co-operative functional interactions between Sp1 & NF-Y are required to direct the activity of the ATP1A3 promoter predominantly in neuronal cells. PMID: 15462673
- trichostatin A activates the transcription of TSP1 gene through the binding of transcription factor CBF to CCAAT box and the enhanced histone acetylation. PMID: 18275041
- CBF-A is a novel transacting factor required for cytoplasmic mRNA transport and localization PMID: 18480411
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亞細胞定位：Nucleus.
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蛋白家族：NFYB/HAP3 subunit family
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數據庫鏈接：
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