NEK4 Antibody
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中文名稱：NEK4兔多克隆抗體
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貨號：CSB-PA225643
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規格：￥1100
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圖片：
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The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA225643(NEK4 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200) -
The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA225643(NEK4 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200)
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其他：
產品詳情
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Uniprot No.：
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基因名：NEK4
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別名：NEK4 antibody; STK2 antibody; Serine/threonine-protein kinase Nek4 antibody; EC 2.7.11.1 antibody; Never in mitosis A-related kinase 4 antibody; NimA-related protein kinase 4 antibody; Serine/threonine-protein kinase 2 antibody; Serine/threonine-protein kinase NRK2 antibody
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宿主：Rabbit
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反應種屬：Human,Mouse
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免疫原：Synthetic peptide of Human NEK4
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：Antigen affinity purification
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
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產品提供形式：Liquid
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應用范圍：ELISA,IHC
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推薦稀釋比：
Application Recommended Dilution ELISA 1:2000-1:5000 IHC 1:25-1:100 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Protein kinase that seems to act exclusively upon threonine residues. Required for normal entry into proliferative arrest after a limited number of cell divisions, also called replicative senescence. Required for normal cell cycle arrest in response to double-stranded DNA damage.
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基因功能參考文獻：
- High NEK4 expression is associated with lung cancer and colorectal cancer. PMID: 27602754
- Nek4 as a novel regulator of replicative senescence and the response to double-stranded DNA damage. PMID: 22851694
- Nek4 interaction with both RPGRIP1 and the RPGRIP1L is involved in cilium assembly. PMID: 21685204
- Data show that after Taxol treatment, Nek4 promoted microtubule outgrowth, whereas Nek4 deficiency impaired G(2)-M arrest and decreased formation of mitotic-like asters. PMID: 20103636
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亞細胞定位：Cell projection, cilium. Cytoplasm.
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蛋白家族：Protein kinase superfamily, NEK Ser/Thr protein kinase family, NIMA subfamily
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組織特異性：Highest expression in adult heart, followed by pancreas, skeletal muscle, brain, testis, retina, liver, kidney, lung and placenta. Present in most primary carcinomas.
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數據庫鏈接：
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