NEK4 Antibody, Biotin conjugated

說明書

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) NEK4 Polyclonal antibody
Uniprot No.：

P51957
基因名：

NEK4
別名：

NEK4 antibody; STK2 antibody; Serine/threonine-protein kinase Nek4 antibody; EC 2.7.11.1 antibody; Never in mitosis A-related kinase 4 antibody; NimA-related protein kinase 4 antibody; Serine/threonine-protein kinase 2 antibody; Serine/threonine-protein kinase NRK2 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Serine/threonine-protein kinase Nek4 protein (516-661AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Biotin
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Protein kinase that seems to act exclusively upon threonine residues. Required for normal entry into proliferative arrest after a limited number of cell divisions, also called replicative senescence. Required for normal cell cycle arrest in response to double-stranded DNA damage.
基因功能參考文獻：
1. High NEK4 expression is associated with lung cancer and colorectal cancer. PMID: 27602754
2. Nek4 as a novel regulator of replicative senescence and the response to double-stranded DNA damage. PMID: 22851694
3. Nek4 interaction with both RPGRIP1 and the RPGRIP1L is involved in cilium assembly. PMID: 21685204
4. Data show that after Taxol treatment, Nek4 promoted microtubule outgrowth, whereas Nek4 deficiency impaired G(2)-M arrest and decreased formation of mitotic-like asters. PMID: 20103636
亞細胞定位：

Cell projection, cilium. Cytoplasm.
蛋白家族：

Protein kinase superfamily, NEK Ser/Thr protein kinase family, NIMA subfamily
組織特異性：

Highest expression in adult heart, followed by pancreas, skeletal muscle, brain, testis, retina, liver, kidney, lung and placenta. Present in most primary carcinomas.
數據庫鏈接：

HGNC: 11399

OMIM: 601959

KEGG: hsa:6787

STRING: 9606.ENSP00000233027

UniGene: Hs.631921

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