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NDUFAF1 Antibody, Biotin conjugated

說明書

中文名稱：

NDUFAF1兔多克隆抗體, Biotin偶聯
貨號：

CSB-PA897101LD01HU
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) NDUFAF1 Polyclonal antibody
Uniprot No.：

Q9Y375
基因名：

NDUFAF1
別名：

CGI 65 antibody; CGI65 antibody; CIA30 antibody; CIA30_HUMAN antibody; Complex I intermediate associated protein 30 antibody; Complex I intermediate associated protein 30 mitochondrial antibody; Complex I intermediate-associated protein 30; mitochondrial antibody; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex assembly factor 1 antibody; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 1 antibody; NADH:ubiquinone oxidoreductase complex assembly factor 1 antibody; NDUFAF 1 antibody; Ndufaf1 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Complex I intermediate-associated protein 30, mitochondrial protein (25-327AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Biotin
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Chaperone protein involved in early stages of the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).
基因功能參考文獻：
1. a case of leukodystrophy associated with mitochondrial complex I deficiency due to a novel mutation in the NDUFAF1 gene. PMID: 24963768
2. oncogenic K-Ras is able to induce significant alterations in mitochondrial protein expression, and identified NDUFAF1 as an important molecule whose low expression contributes to mitochondrial dysfunction induced by K-Ras. PMID: 25714130
3. NDUFAF1 is an important protein for the assembly/stability of complex I (NADH:ubiquinone oxidoreductase). PMID: 16218961
4. Study shows a mitochondrial function for Ecsit in the assembly of mitochondrial complex I, an N-terminal targeting signal directs Ecsit to mitochondria, where it interacts with assembly chaperone NDUFAF1. PMID: 17344420
5. the involvement of NDUFAF1 in the assembly process could be indirect rather than direct via the binding to assembly intermediates PMID: 17383918
6. CIA30 is a crucial component in the early assembly of complex I and mutations in its gene can cause mitochondrial disease PMID: 17557076
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亞細胞定位：

Mitochondrion. Mitochondrion matrix.
蛋白家族：

CIA30 family
組織特異性：

Ubiquitous.
數據庫鏈接：

HGNC: 18828

OMIM: 606934

KEGG: hsa:51103

STRING: 9606.ENSP00000260361

UniGene: Hs.106529

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