NCR1 Antibody
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中文名稱：NCR1兔多克隆抗體
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貨號：CSB-PA003455
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規格：￥1090
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圖片：
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Western Blot analysis of A549 cells using NKp46 Polyclonal Antibody
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其他：
產品詳情
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Uniprot No.：
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基因名：
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別名：NCR1; LY94; Natural cytotoxicity triggering receptor 1; Lymphocyte antigen 94 homolog; NK cell-activating receptor; Natural killer cell p46-related protein; NK-p46; NKp46; hNKp46; CD antigen CD335
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宿主：Rabbit
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反應種屬：Human
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免疫原：Synthesized peptide derived from the Internal region of Human NKp46.
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產品提供形式：Liquid
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應用范圍：WB, ELISA
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 ELISA 1:10000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.
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基因功能參考文獻：
- this paper shows that the decreased expression of activating receptor NKp46 on peripheral blood NK cells is positively associated with gastric cancer progression PMID: 30255106
- HIF-1alpha inhibits NCR1/NKp46 pathway through up-regulating miR-224, which affects the killing capability of NK cells on prostate cancer, thus inducing immune escape of tumor cells. PMID: 29885835
- The authors demonstrated that mutant NKp46 W32R is aberrantly glycosylated, accumulates in the endoplasmic reticulum, and is unstable on the cell surface. PMID: 28134248
- Low NKp46 expression on on NK cells is associated with Nasopharyngeal Carcinoma. PMID: 29580037
- Signaling via the natural killer cell receptor NKp46 (human) and Ncr1 (mouse) induced interferon-gamma (IFN-gamma) secretion from intratumoral natural killer cells. PMID: 29329948
- findings show HIV reservoir size is dependent on the presence of a defined NK cell population with a specific transcriptional signature: high NCR (NKp46 and NKp30) and IFN-gamma inducibility upon NCR and cytokine receptor engagement PMID: 28956765
- NKp46 cleavage by Cathepsin G severely impairs NKp46-mediated responses of Natural killer cells. PMID: 27587403
- The NKp46 and NKp46-ligand interaction contributes to NK cell activation. PMID: 28328926
- this study shows that the NKp46-activating receptor recognizes an unknown ligand expressed by human metapneumovirus-infected cells PMID: 28191644
- Intrahepatic NKp46 NK cells exhibited anti-HCV activity via cell-to-cell contact. The variation of the NKp46 proportion in individuals could be attributed to the diversity of HCV resistance observed in these individuals. PMID: 26714120
- Taken together, these results demonstrate that endogenous levels of IFN-alpha secreted by plasmacytoid dendritic cells induce natural killer cells to lyse HIV-1-infected autologous CD4+ primary T cells via the engagement of NKp46 and NKG2D. PMID: 26372382
- NKp46 was thus involved in the production of serine proteases and interleukin-22 in human mast cells. PMID: 25940096
- Age and CMV serostatus influence the expression of NKp30, NKp46 and DNAM-1 activating receptors on resting and IL-2 activated natural killer cells. PMID: 25991472
- Ncr1-Noe proteins accumulate in the endoplasmic reticulum, and that the expression of Ncr1-Noe proteins, but not WT Ncr1, leads to increased Helios expression PMID: 26371250
- Data show that regulatory dendritic cells (regDC) restrain IFN-gamma secretion by NK cells through secretion of interleukin-10 (IL-10), engagement of MHC class I-specific inhibitory receptors, and the activating receptor NKp46. PMID: 26232426
- Expression of NKp46/NCR1 in NK cells was significantly higher in untreated severe aplastic anemia patients than those in remission SAA and controls. This may be the reason for the hyperfunction of the immune system in SAA patients. PMID: 26554241
- Downregulated NKG2D, NKp46, and DNAM-1 receptors associated with impaired NK cell effector function are important biomarkers of advanced disease with a poor prognosis in melanoma patients. PMID: 24769842
- Women, w/ or w/o endometriosis, having larger populations of cytotoxic CD16(+) uterine NK cells and/or higher populations of NKp46(+)CD56(+) cells may be at greater risk of infertility resulting from inflammatory environment during implantation or later PMID: 24807109
- IL-15+IL-12 has an immunomodulatory effect on NK cell subsets from HIV-infected individuals viz down-regulation of iNKRs, elevation of activatory receptors NKp46 and NKG2D, and induction of coreceptor NKp80. PMID: 22715368
- NKp46 marks out pathologically activated natural killer cells, which may result from a loss of homeostatic control of activating receptor expression in hepatitis C virus. PMID: 23665989
- NKp46 is expressed on CD4 lymphocytes in mycosis fungoides and Sezary syndrome. PMID: 23900021
- Cytokine stimulation combined with natural killer cell receptor engagement are required for human natural killer cell functional diversity. PMID: 23490421
- involved in cytokine production of CD56+ NK cells in the uterine endometrium PMID: 23311919
- PLS3, Twist, KIR3DL2 and NKp46 gene expression can model efficient molecular Sezary syndrome diagnosis. PMID: 23429988
- NKp46 expression of hepatitis C virus replication controls the modulation of liver fibrosis. PMID: 22532190
- Race and gender related variation found in NKp46 receptor expression with differential anti-hepatitis C virus immunity. PMID: 22505144
- expressed in all investigated cases of transformed mycosis fungoides PMID: 22621189
- We suggest that NKp46 dimerization contributes to NKp46-mediated lysis by NK cells. PMID: 22615207
- NKp46 levels remain stable on the natural killer cells that persist at one week post-liver transplant in pediatric patients. PMID: 22360401
- important role in inhibition of liver fibrosis PMID: 22198715
- This study demonistrated that NCR1 expression on astrocytes in MS tissue. PMID: 22212381
- Role of runt-related transcription factor 3 (RUNX3) in transcription regulation of natural cytotoxicity receptor 1 (NCR1/NKp46), an activating natural killer (NK) cell receptor. PMID: 22253448
- findings show that NK cells can significantly accelerate neutrophil apoptosis, and that this process is dependent on cell-cell contact and mediated by the activating NK cell receptor NKp46 and the Fas pathway PMID: 22231698
- decreased expression is associated with altered NK-cell function in pediatric transplant patients with PTLD PMID: 22105417
- we investigate whether NKp46 is involved in the killing of human beta cells PMID: 21849674
- NKp46 identifies a functionally distinct NKT subset in that appears to be directly susceptible to leukemic transformation when IL-15 is overexpressed. PMID: 21364281
- Data show that an increase in 2B4-expressing NK cells and a decrease in NKp46(+) NK cells occurred following intramuscular influenza vaccination. PMID: 21214542
- peripheral blood malignant CD4(+) T lymphocytes from patients with Sezary syndrome, an aggressive form of cutaneous T-cell lymphoma, express NKp46 at their cell surface PMID: 21191411
- NKp46 interacts with heparin and heparan sulfate, highly sulfated glycans, and multimeric alpha2,3-NeuAc-containing N-glycan; these glycans interact mainly with basic amino acids in NKp46. PMID: 21329668
- Data show that only NKp46 appeared involved in the NK response. PMID: 21030563
- NKp46 is essential for the development of type 1 diabetes PMID: 20023661
- The NKp46 receptor participates in NK cell-mediated lysis of cells infected with the intracellular pathogen Mycobacterium tuberculosis, an activity that is reduced in tuberculosis patients compared with findings in healthy donors. PMID: 11907104
- crystal structure of the human natural killer (NK) cell activating receptor NKp46 PMID: 12960161
- NKp46 interacts with both viral hemagglutinins and the unknown tumor ligands via different mechanisms. PMID: 14504081
- CD59 is physically associated with NKp46 and NKp30 and activate human nk cell-mediated cytotoxicity. PMID: 14635045
- natural cytotoxicity receptor (NCR) and NK receptor member D of the lectin-like receptor family (NKG2D) were the key NK activating receptors for bone marrow-derived myeloma cell recognition PMID: 15328155
- NKp46 is not only a triggering molecule essential for antitumor activity but is also a surface receptor involved in natural killer cell suicide. PMID: 15728472
- Results examine residues in NKp46 that may be involved in heparan sulfate binding on tumor cells. PMID: 16262248
- defect in cytotoxic effector function is associated with a reduced surface expression of activating NK receptors (NKp30, NKp46, and NKG2D) on CD56(dim) NK cells compared with uninfected newborns. PMID: 16690951
- The natural cytotoxicity receptor NKp46 was required for the killing of all myeloma cell lines analyzed. PMID: 17875681
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亞細胞定位：Cell membrane; Single-pass type I membrane protein.
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蛋白家族：Natural cytotoxicity receptor (NCR) family
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組織特異性：Selectively expressed by both resting and activated NK cells.
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