MYH2 Antibody
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中文名稱：MYH2兔多克隆抗體
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貨號：CSB-PA015296GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：MYH2
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別名：adult 2 antibody; Fast 2a myosin heavy chain antibody; IBM3 antibody; Inclusion body myopathy 3, autosomal dominant antibody; MYH2 antibody; MYH2_HUMAN antibody; MYH2A antibody; MYHas8 antibody; MyHC IIa antibody; MyHC-2a antibody; MyHC-IIa antibody; MYHSA2 antibody; Myosin heavy chain 2 antibody; Myosin heavy chain 2a antibody; Myosin heavy chain antibody; Myosin heavy chain IIa antibody; Myosin heavy chain skeletal muscle adult 2 antibody; Myosin heavy polypeptide 2 skeletal muscle adult antibody; Myosin-2 antibody; MYPOP antibody; skeletal muscle antibody; Type IIA myosin heavy chain antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Human MYH2
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：0.1M NaHCO3,0.1M Glycine, 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,WB
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Muscle contraction. Required for cytoskeleton organization.
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基因功能參考文獻：
- Exome analysis revealed homozygosity for a novel truncating mutation p.G800fs27* in the Myosin Heavy Chain 2 (MYH2) gene in both brothers, while parents and an unaffected sibling were heterozygous PMID: 28729039
- differential regulation of PKA and cell stiffness in unconfined versus confined cells is abrogated by dual, but not individual, inhibition of Piezo1 and myosin II. PMID: 27160899
- C-terminal Myosin IIA Heavy Chain phosphorylation sites are critical for recruitment of Myosin IIA to lamellar protrusions and for marginal paxillin phosphorylation during active cell spreading. PMID: 28053086
- Data shoe that five of the patients were homozygous for myosin heavy chain 2 (MYH2) missense mutations, one patient was compound heterozygous for a missense and a nonsense mutation and one patient was homozygous for a frame-shift MYH2 mutation. PMID: 24193343
- We have found that a greater MyH2 content in the vastus lateralis is accompanied by a higher oxygen cost of cycling during exercise performed below the lactate threshold. PMID: 24781731
- This study presented more case in MYH2 mutation in recessive myopathy with external ophthalmoplegia linked to chromosome 17p13.1-p12. PMID: 23388406
- A previously unrecognized interplay between actin and myosin IIA in podosomes, is demonstrated. PMID: 23361003
- Myosin heavy chain 2A transcripts decreased significantly in skeletal muscle tissue from overnight parenterally fed patients but did not change significantly in orally refed mice PMID: 23190566
- Phenotypic expression of alpha-smooth muscle actin, smooth muscle myosin heavy chain 2, and smoothelin were significantly decreased in the dissected media, whereas that of osteopontin was elevated. PMID: 22960022
- This study demonistrated that the missense mutation c.2542T>C (p.V805A) in the MYHC2A gene. PMID: 22349865
- The human genioglossus muscle is composed of conventional myosin heavy chain isoforms and 3 primary myosin hevy chain phenotypes. PMID: 22337492
- NMMII and actin isoform expression changes coordinately with the remodeling phase of repair, and NMMII is increased as matrix stiffness increases. As NMMII expression increases, so does the fibroblast contractility. PMID: 21102503
- Null mutations in the fast myosin heavy chain IIa gene cause early onset myopathy and demonstrate that this isoform is necessary for normal muscle development and function. PMID: 20418530
- investigated the relation between expression of the mutant MyHC IIa and pathologic changes in muscle PMID: 11889243
- Data suggest that changes in intracellular calcium may play a role in shifts in myosin heavy chain IIa (MyHC IIa) expression during muscle activation. PMID: 12235157
- IRF-2 is involved in up-regulation of nonmuscle myosin heavy chain II-A gene expression in cell differentiation PMID: 15496418
- analysis of normal variation indicates that there is strong selective pressure against mutations in MYH2; On the basis of these results, we suggest that MyHC genes should be regarded as candidate genes in hereditary myopathies of unknown etiology. PMID: 15741996
- Our results provide evidence that the pathogenesis of the MyHC IIa E706K myopathy involves defective function of the mutated myosin as well as alterations in the structural integrity of all muscle cells irrespective of MyHC isoform expression. PMID: 17005402
- myosin II has a role in glioma invasion of the brain PMID: 18495866
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相關疾病：Myopathy, proximal, and ophthalmoplegia (MYPOP)
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亞細胞定位：Cytoplasm, myofibril. Note=Thick filaments of the myofibrils.
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蛋白家族：TRAFAC class myosin-kinesin ATPase superfamily, Myosin family
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數據庫鏈接：
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