Recombinant Human Myosin-2 (MYH2), partial

中文名稱：

人MYH2重組蛋白
貨號：

CSB-YP892458HU
規(guī)格：
來源：

Yeast
其他：

中文名稱：

人MYH2重組蛋白
貨號：

CSB-EP892458HU
規(guī)格：
來源：

E.coli
其他：

中文名稱：

人MYH2重組蛋白
貨號：

CSB-EP892458HU-B
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人MYH2重組蛋白
貨號：

CSB-BP892458HU
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

人MYH2重組蛋白
貨號：

CSB-MP892458HU
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

MYH2
Uniprot No.：

Q9UKX2
別名：

adult 2; Fast 2a myosin heavy chain; IBM3; Inclusion body myopathy 3, autosomal dominant; MYH2; MYH2_HUMAN; MYH2A; MYHas8; MyHC IIa; MyHC-2a; MyHC-IIa; MYHSA2; Myosin heavy chain 2; Myosin heavy chain 2a; Myosin heavy chain; Myosin heavy chain IIa; Myosin heavy chain skeletal muscle adult 2; Myosin heavy polypeptide 2 skeletal muscle adult; Myosin-2; MYPOP; skeletal muscle; Type IIA myosin heavy chain
種屬：

Homo sapiens (Human)
蛋白長度：

Partial
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

Muscle contraction. Required for cytoskeleton organization.
基因功能參考文獻(xiàn)：
1. Exome analysis revealed homozygosity for a novel truncating mutation p.G800fs27* in the Myosin Heavy Chain 2 (MYH2) gene in both brothers, while parents and an unaffected sibling were heterozygous PMID: 28729039
2. differential regulation of PKA and cell stiffness in unconfined versus confined cells is abrogated by dual, but not individual, inhibition of Piezo1 and myosin II. PMID: 27160899
3. C-terminal Myosin IIA Heavy Chain phosphorylation sites are critical for recruitment of Myosin IIA to lamellar protrusions and for marginal paxillin phosphorylation during active cell spreading. PMID: 28053086
4. Data shoe that five of the patients were homozygous for myosin heavy chain 2 (MYH2) missense mutations, one patient was compound heterozygous for a missense and a nonsense mutation and one patient was homozygous for a frame-shift MYH2 mutation. PMID: 24193343
5. We have found that a greater MyH2 content in the vastus lateralis is accompanied by a higher oxygen cost of cycling during exercise performed below the lactate threshold. PMID: 24781731
6. This study presented more case in MYH2 mutation in recessive myopathy with external ophthalmoplegia linked to chromosome 17p13.1-p12. PMID: 23388406
7. A previously unrecognized interplay between actin and myosin IIA in podosomes, is demonstrated. PMID: 23361003
8. Myosin heavy chain 2A transcripts decreased significantly in skeletal muscle tissue from overnight parenterally fed patients but did not change significantly in orally refed mice PMID: 23190566
9. Phenotypic expression of alpha-smooth muscle actin, smooth muscle myosin heavy chain 2, and smoothelin were significantly decreased in the dissected media, whereas that of osteopontin was elevated. PMID: 22960022
10. This study demonistrated that the missense mutation c.2542T>C (p.V805A) in the MYHC2A gene. PMID: 22349865
11. The human genioglossus muscle is composed of conventional myosin heavy chain isoforms and 3 primary myosin hevy chain phenotypes. PMID: 22337492
12. NMMII and actin isoform expression changes coordinately with the remodeling phase of repair, and NMMII is increased as matrix stiffness increases. As NMMII expression increases, so does the fibroblast contractility. PMID: 21102503
13. Null mutations in the fast myosin heavy chain IIa gene cause early onset myopathy and demonstrate that this isoform is necessary for normal muscle development and function. PMID: 20418530
14. investigated the relation between expression of the mutant MyHC IIa and pathologic changes in muscle PMID: 11889243
15. Data suggest that changes in intracellular calcium may play a role in shifts in myosin heavy chain IIa (MyHC IIa) expression during muscle activation. PMID: 12235157
16. IRF-2 is involved in up-regulation of nonmuscle myosin heavy chain II-A gene expression in cell differentiation PMID: 15496418
17. analysis of normal variation indicates that there is strong selective pressure against mutations in MYH2; On the basis of these results, we suggest that MyHC genes should be regarded as candidate genes in hereditary myopathies of unknown etiology. PMID: 15741996
18. Our results provide evidence that the pathogenesis of the MyHC IIa E706K myopathy involves defective function of the mutated myosin as well as alterations in the structural integrity of all muscle cells irrespective of MyHC isoform expression. PMID: 17005402
19. myosin II has a role in glioma invasion of the brain PMID: 18495866
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相關(guān)疾病：

Myopathy, proximal, and ophthalmoplegia (MYPOP)
亞細(xì)胞定位：

Cytoplasm, myofibril. Note=Thick filaments of the myofibrils.
蛋白家族：

TRAFAC class myosin-kinesin ATPase superfamily, Myosin family
數(shù)據(jù)庫鏈接：

HGNC: 7572

OMIM: 160740

KEGG: hsa:4620

STRING: 9606.ENSP00000245503

UniGene: Hs.667534