MPZL1 Antibody, FITC conjugated

說明書

中文名稱：

MPZL1兔多克隆抗體, FITC偶聯
貨號：

CSB-PA014775LC01HU
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) MPZL1 Polyclonal antibody
Uniprot No.：

O95297
基因名：

MPZL1
別名：

MPZL1; PZR; UNQ849/PRO1787; Myelin protein zero-like protein 1; Protein zero-related
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Myelin protein zero-like protein 1 protein (195-258AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

FITC
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Cell surface receptor, which is involved in signal transduction processes. Recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2. Is a major receptor for concanavalin-A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine-protein kinases. Isoform 3 seems to have a dominant negative role; it blocks tyrosine phosphorylation of MPZL1 induced by ConA. Isoform 1, but not isoform 2 and isoform 3, may be involved in regulation of integrin-mediated cell motility.
基因功能參考文獻：
1. MPZL1 is a target gene within the 1q24.1-24.2 amplicon that plays a pivotal role in HCC cell migration and tumor metastasis, and a novel MPZL1/Src/cortactin signaling cascade. PMID: 24296779
2. Clinico-electrophysiological features and MRI findings are described in leg musculature from three patients belonging to a CMT2J pedigree due to MPZ Thr124Met mutation. PMID: 19629567
3. PZR is a major receptor of ConA and has an important role in cell signaling via c-Src. Considering the various biological activities of ConA, the study of PZR may have major therapeutic implications PMID: 11751924
4. Characterization of PZR1b, an alternative spliced isoform of PZR. PMID: 12684038
5. the MPZL1/PZR gene may be important in the predisposition to schizophrenia among Han Chinese PMID: 16702974
6. Phosphorylation and localization of PZR in cultured endothelial cells is reported. PMID: 18568953
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亞細胞定位：

Membrane; Single-pass type I membrane protein.
蛋白家族：

Myelin P0 protein family
組織特異性：

Widely expressed with highest levels in heart, placenta, kidney and pancreas. Isoform 3 is relatively abundant in hematopoietic tissues and fetal liver. Isoform 1 and isoform 3 are expressed in CD14- PB monocytes and pre-B cell progenitors. Isoform 3 appe
數據庫鏈接：

HGNC: 7226

OMIM: 604376

KEGG: hsa:9019

STRING: 9606.ENSP00000352513

UniGene: Hs.493919

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