MFAP4 Antibody

中文名稱：

MFAP4兔多克隆抗體
貨號：

CSB-PA013749LA01HU
規格：

￥440
圖片：
IHC image of CSB-PA013749LA01HU diluted at 1:300 and staining in paraffin-embedded human prostate cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

IHC image of CSB-PA013749LA01HU diluted at 1:300 and staining in paraffin-embedded human cervical cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
其他：

產品詳情
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) MFAP4 Polyclonal antibody
Uniprot No.：

P55083
基因名：

MFAP4
別名：

MFAP4 antibody; MFAP4_HUMAN antibody; Microfibril-associated glycoprotein 4 antibody; Microfibrillar associated protein 4 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Microfibril-associated glycoprotein 4 protein (100-191AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，MFAP4 Antibody (CSB-PA013749LA01HU)，的標記方式是Non-conjugated。對于MFAP4 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA013749LB01HU	MFAP4 Antibody, HRP conjugated	ELISA
FITC	CSB-PA013749LC01HU	MFAP4 Antibody, FITC conjugated
Biotin	CSB-PA013749LD01HU	MFAP4 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:200-1:500

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Could be involved in calcium-dependent cell adhesion or intercellular interactions. May contribute to the elastic fiber assembly and/or maintenance.
基因功能參考文獻：
1. the applicability of MFAP4 as a novel serum biomarker for assessment of hepatic fibrosis and identification of high-risk patients with severe fibrosis stages in hepatitis C, is reported. PMID: 27378383
2. No association between pMFAP4 and macrovascular vascular complications was found. However, high levels of pMFAP4 correlated independently with diabetic neuropathy. PMID: 28039584
3. These studies have identified and validated new factors enriched in juvenile chondrocytes as compared to adult chondrocytes including secreted extracellular matrix factors chordin-like 1 (CHRDL1) and microfibrillar-associated protein 4 (MFAP4). PMID: 26955889
4. plasma MFAP4 was significantly increased among patients with a previous diagnosis of liver disease or congestive heart failure compared to patients with other diagnoses. PMID: 26460565
5. Data suggest that MFAP4 specifically binds tropoelastin and fibrillin-1/-2, as well as elastin cross-linking amino acid desmosine; MFAP4 co-localizes with fibrillin-1-positive fibers; MFAP4 actively promotes tropoelastin self-assembly. PMID: 26601954
6. MFAP4 regulates integrin alphaVbeta3-induced VSMC proliferation and migration, as well as monocyte chemotaxis, and accelerates neointimal hyperplasia after vascular injury. PMID: 26564819
7. Serum MFAP4 varies in groups of patients with different cardiovascular conditions. PMID: 24349233
8. The findings support the biomarker potential of systemic MFAP4, with elevated levels in the serum reflecting pathological processes involving ECM remodeling and degradation. PMID: 24324779
9. skin with enhanced MFAP-4 expression was protected from UVB-induced photodamage/photoaging accompanied by the prevention of ECM degradation and aggravated elasticity PMID: 22355679
10. Microfibrillar associated protein 4 binds pulmonary surfactant protein A (SP-A) and colocalizes with SP-A in the extracellular matrix of the lung. PMID: 16867155
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亞細胞定位：

Secreted, extracellular space, extracellular matrix.
數據庫鏈接：

HGNC: 7035

OMIM: 600596

KEGG: hsa:4239

STRING: 9606.ENSP00000378957

UniGene: Hs.296049

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