MAT2B Antibody

說明書

中文名稱：

MAT2B兔多克隆抗體
貨號：

CSB-PA013518GA01HU
規格：

￥3,900
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

Q9NZL9
基因名：

MAT2B
別名：

1110064C04Rik antibody; 2410018D16Rik antibody; AI182287 antibody; AU022853 antibody; Beta regulatory subunit of methionine adenosyltransferase antibody; dTDP 4 keto 6 deoxy D glucose 4 reductase antibody; DTDP-4-keto-6-deoxy-D-glucose 4-reductase antibody; MAT II antibody; MAT II beta antibody; Mat2b antibody; MAT2B_HUMAN antibody; MATIIbeta antibody; Methionine adenosyltransferase 2 beta subunit antibody; Methionine adenosyltransferase 2 subunit beta antibody; Methionine adenosyltransferase II beta antibody; MGC12237 antibody; MSTP045 antibody; Nbla02999 antibody; OTTMUSP00000005600 antibody; Putative dTDP-4-keto-6-deoxy-D-glucose 4-reductase antibody; Putative protein product of Nbla02999 antibody; RP23-382C18.2 antibody; SDR23E1 antibody; Short chain dehydrogenase/reductase family 23E member 1 antibody; TGR antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Human MAT2B
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產品提供形式：

Liquid
應用范圍：

ELISA,WB,IHC,IF
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine. Can bind NADP (in vitro).
基因功能參考文獻：
1. Results show that MAT2B expression is frequently upregulated in malignant melanoma tissues. MAT2B downregulation delays tumor growth in vivo, and suppressed cell growth, colony formation ability and induced apoptosis in vitro indicating that MAT2B is critical for melanoma cell proliferation and tumorigenicity. PMID: 27573889
2. Interaction between MAT2B and GIT1 serves as a scaffold and facilitates signaling in multiple steps of the Ras/Raf/MEK/ERK pathway PMID: 25794709
3. Mutagenesis of MATalpha2 and MATbeta phospho-sites destabilized them and prevented hepatic stellate cell trans-differentiation. PMID: 25294683
4. MAT2B and GIT1 form a scaffold, which recruits and activates MEK and ERK to promote growth and tumorigenesis. PMID: 23325601
5. The structure of MAT2B reveals a short-chain dehydrogenase/reductase (SDR) core with specificity for the NADP/H cofactor, and harbors the SDR catalytic triad. PMID: 23425511
6. Coexpression of MAT2A and MAT2B in COS-1 cells resulted in significantly increased MAT enzyme activity. PMID: 21813468
7. Data show MAT2beta variants reside mostly in the nucleus and regulate HuR subcellular content to affect cell proliferation. PMID: 20421296
8. Lower expression of both MAT2A and MAT2beta and interfere with leptin signaling in liver cancer cells. PMID: 18041713
9. Splicing variants of MAT2beta are up-regulated in hepatocellular carcinoma and regulated tumor cell growth and death. PMID: 18045590
10. a switch in MAT expression in liver cancer was accompanied by increasing expression of MAT2B PMID: 18698677
11. differences in malignant cell survival, effected by MAT-IIbeta ablation, suggest that it may be possible to use this approach to disadvantage leukemic cell survival in vivo with little to no harm to normal cells. PMID: 18753136
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蛋白家族：

DTDP-4-dehydrorhamnose reductase family, MAT2B subfamily
組織特異性：

Widely expressed.
數據庫鏈接：

HGNC: 6905

OMIM: 605527

KEGG: hsa:27430

STRING: 9606.ENSP00000325425

UniGene: Hs.54642

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