LTB Antibody

說明書

中文名稱：

LTB兔多克隆抗體
貨號：

CSB-PA823426
規格：

￥1090
圖片：
Immunohistochemical analysis of paraffin-embedded human-liver, antibody was diluted at 1:200

Immunohistochemical analysis of paraffin-embedded human-spleen, antibody was diluted at 1:200

Immunohistochemical analysis of paraffin-embedded human-spleen, antibody was diluted at 1:200
其他：

產品詳情
產品評價
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靶點詳情

產品詳情

Uniprot No.：

Q06643
基因名：

LTB
別名：

LT beta antibody; LT-beta antibody; Ltb antibody; lymphotoxin beta antibody; Lymphotoxin-beta antibody; p33 antibody; TNF-C antibody; TNFC antibody; TNFC_HUMAN antibody; TNFSF3 antibody; Tumor necrosis factor C antibody; Tumor necrosis factor ligand superfamily member 3 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Synthetic peptide from Human protein at AA range: 41-90
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
純化方式：

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

IHC,ELISA

推薦稀釋比：

Application	Recommended Dilution
IHC	IHC-p:1:50-300
ELISA	1:10000-20000

Protocols：

Immunohistochemistry (IHC) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface. Isoform 2 is probably non-functional.
基因功能參考文獻：
1. Combination of an EGFR tyrosine kinase inhibitor and a NF-kappaB inhibitor effectively suppressed cetuximab-resistant HNSCC and interfering with the EGFR-LTbeta interaction reverses resistance. PMID: 28196873
2. TNF is able to upregulate LT-beta expression in hepatic cells at the transcriptional level by the binding of NF-kappaB p50/p65 heterodimers and Ets1 to their respective sites in the LT-beta promoter. PMID: 22742857
3. The multifaceted character of lymphotoxin beta may be involved in inflammatory myopathies and muscular dystrophies. PMID: 22652080
4. Data show differential expression of interferon-gamma, TNFSF3, TNFSF10, TNFSF12 and PDGFbeta in CD8+, CD14+ and CD4+ cells. PMID: 21211989
5. Findings provide evidence of additional complexity in the transcriptional regulation of LTB with implications for coordinate expression of genes in this important genomic locus. PMID: 21248773
6. Heterotypic interaction between LTbeta-producing lymphocytes and responding fibroblast-like synoviocytes contributes to establishment of complex lymphoid microstructures. May be one element in susceptibility of synovial membrane to lymphoid organogenesis. PMID: 15248211
7. The identification of IL-6 and IL-1beta as activators of LT-beta supports their involvement in LT-beta signaling in liver regeneration associated with chronic liver damage. PMID: 15910501
8. Lymphotoxin (LT) beta receptor ligands LTalpha1 and -beta2 activate both the classical and noncanonical NF-kappa B pathways in human vascular endothelial cells and dermal microvascular endothelial cells in vitro. PMID: 18292573
9. LT-Beta may play a role in rheumatoid arthritis disease pathogenesis by contributing to a more intense inflammatory reaction in the synovium PMID: 18379788
10. blocking the lymphotoxin-beta receptor pathway results in ablation of the lymphoid organization in the NOD salivary glands and thus an improvement in salivary gland function. PMID: 19222863
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亞細胞定位：

Membrane; Single-pass type II membrane protein.
蛋白家族：

Tumor necrosis factor family
組織特異性：

Spleen and thymus.
數據庫鏈接：

HGNC: 6711

OMIM: 600978

KEGG: hsa:4050

STRING: 9606.ENSP00000410481

UniGene: Hs.376208

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