LGALS4 Antibody

中文名稱：

LGALS4兔多克隆抗體
貨號：

CSB-PA012889LA01HU
規格：

￥440
圖片：
IHC image of CSB-PA012889LA01HU diluted at 1:100 and staining in paraffin-embedded human small intestine tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Immunofluorescence staining of A549 cells with CSB-PA012889LA01HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
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靶點詳情

產品詳情

產品描述：

The Rabbit anti-Homo sapiens (Human) LGALS4 Polyclonal antibody is produced in rabbits using Recombinant Human Galectin-4 protein (1-323AA). It is validated for ELISA, IF, and IHC. This antibody reacts with Human Galectin-4 (LGALS4), a protein involved in intracellular and intercellular interactions.
Galectin-4 belongs to a family of proteins that bind to beta-galactoside. It plays a role in cancer and inflammatory diseases of the intestine.
The levels of Galectin-4 in the body have been shown to rise as cancer progresses, making it a possible tumor marker. In inflammatory diseases of the intestine, Galectin-4 stimulates the production of mediators that worsen inflammation.
The Rabbit anti-Homo sapiens (Human) LGALS4 Polyclonal Antibody can be used in research to detect the presence of Galectin-4, a possible tumor marker.
產品名稱：

Rabbit anti-Homo sapiens (Human) LGALS4 Polyclonal antibody
Uniprot No.：

P56470
基因名：

LGALS4
別名：

Antigen NY CO 27 antibody; Antigen NY-CO-27 antibody; Antigen NYCO27 antibody; GAL 4 antibody; Gal-4 antibody; GAL4 antibody; Galectin 4 antibody; Galectin-4 antibody; Galectin4 antibody; Homo sapiens galectin4 mRNA complete cds antibody; L 36 lactose binding protein antibody; L-36 lactose-binding protein antibody; L36 lactose binding protein antibody; L36LBP antibody; Lactose binding lectin 4 antibody; Lactose-binding lectin 4 antibody; Lectin galactoside binding soluble 4 antibody; LEG4_HUMAN antibody; LGALS4 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Galectin-4 protein (1-323AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，LGALS4 Antibody (CSB-PA012889LA01HU)，的標記方式是Non-conjugated。對于LGALS4 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA012889LB01HU	LGALS4 Antibody, HRP conjugated	ELISA
FITC	CSB-PA012889LC01HU	LGALS4 Antibody, FITC conjugated
Biotin	CSB-PA012889LD01HU	LGALS4 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Galectin that binds lactose and a related range of sugars. May be involved in the assembly of adherens junctions.
基因功能參考文獻：
1. Data show that galectin-4 expressing tumor cells interact directly with red blood cells (RBCs). PMID: 28293788
2. Haplotype formed from two promoter SNPs rs116896264 and rs73933062 is associated with galectin-4 overexpression in colorectal cancer. PMID: 26681582
3. LGALS4 may function as a tumor suppressor gene in UC progression. Findings provide evidence that methylation-mediated LGALS4 gene repression may be involved in urothelial tumor progression. PMID: 28423602
4. Together, the data demonstrated that surface-bound galectin-4 is a dual function protein-down-regulating cell proliferation and chemokine secretion in galectin-4-expressing colorectal cancer cells on one hand and inducing apoptosis in galectin-4-negative colorectal cancer cells on the other hand. PMID: 28345468
5. The carbohydrate-binding site is composed of residues His236, Asn238, Arg240, Asn249, Trp256, Glu259 and Lys261 at the strands S4, S5 and S6. PMID: 26432949
6. The data suggests that arm-Gal4 has detrimental effects on Drosophila development and lifespan that are directly dependent upon parental inheritance PMID: 26505429
7. The co-expression of galectin-4 and CNT3 proteins is not impaired in inflamed colon from patients with Crohn's disease, thereby anticipating the integrity of this system for drug targeting. PMID: 26481311
8. Structural characterization of human galectin 4 C-terminal domain in terms its ligands binding specificity has been reported. PMID: 26077389
9. role in basolateral to apical epithelial transcytosis PMID: 25179596
10. The results show galectin-4 expression closely associates with hepatocellular carcinoma (HCC) progression and might have potential use as a prognostic biomarker for HCC patients. PMID: 25230111
11. Galectin-4 plays an important role in metastatic process of lung adenocarcinoma. PMID: 24339976
12. Data indicate that galectin-4 elicits tumor promotion in vitro and in vivo through activation of IL-6/NF-kappaB/STAT3 signaling. PMID: 23378274
13. Loss of Galectin-4 is associated with colorectal cancer. PMID: 21064109
14. crystals of galectin-4 belonged to space group P6(1)22, with unit-cell parameters a = b = 71.25, c = 108.66 A. PMID: 20445255
15. microarray study in sinonasal adenocarcinoma we identified proteins, LGALS4 that is significantly differentially expressed in tumors compared to normal tissue PMID: 19903339
16. results suggest that galectin-4 has a unique carbohydrate binding specificity and interacts with O-linked sulfoglycans PMID: 11971864
17. SB1a and CEA in the patches on the cell surface of human colon adenocarcinoma cells could be biologically important ligands for galectin-4 PMID: 15546874
18. Together, our data propose that interaction between galectin-4 and sulfatides plays a functional role in the clustering of lipid rafts for apical delivery. PMID: 15883199
19. Galectin 4 induces surface phosphatidylserine exposure in a carbohydrate-dependent fashion in activated, but not resting, human neutrophils and in several leukocyte cell lines. PMID: 16940423
20. not only sulfated glycosphingolipids but also cholesterol 3-sulfate are endogenous ligands for galectin-4 in vivo PMID: 17545668
21. chemical analysis of talose-selectivity of galectin-4 and galectin-8 PMID: 18539029
22. Data show that the pattern of N-glycosylation of glycoproteins serves as a recognition signal for endocytosed galectin-4, which drives the raft-dependent apical pathway of glycoproteins in enterocyte-like HT-29 cells. PMID: 19192249
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數據庫鏈接：

HGNC: 6565

OMIM: 602518

KEGG: hsa:3960

STRING: 9606.ENSP00000302100

UniGene: Hs.5302

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