LGALS4 Antibody
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中文名稱：LGALS4兔多克隆抗體
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貨號：CSB-PA787674
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規(guī)格：￥2024
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圖片：
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Western blot analysis of extracts from HeLa cells, using LEG7 antibody. -
Immunohistochemistry analysis of paraffin-embedded human liver carcinoma tissue using LEG4 antiobdy.
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其他：
產(chǎn)品詳情
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產(chǎn)品名稱：Rabbit anti-Homo sapiens (Human) LGALS4 Polyclonal antibody
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Uniprot No.：
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基因名：LGALS4
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宿主：Rabbit
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反應(yīng)種屬：Human
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免疫原：Synthesized peptide derived from internal of Human LEG4.
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免疫原種屬：Homo sapiens (Human)
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克隆類型：Polyclonal
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA,WB,IHC
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:3000 IHC 1:50-1:100 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情
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功能：Galectin that binds lactose and a related range of sugars. May be involved in the assembly of adherens junctions.
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基因功能參考文獻：
- Data show that galectin-4 expressing tumor cells interact directly with red blood cells (RBCs). PMID: 28293788
- Haplotype formed from two promoter SNPs rs116896264 and rs73933062 is associated with galectin-4 overexpression in colorectal cancer. PMID: 26681582
- LGALS4 may function as a tumor suppressor gene in UC progression. Findings provide evidence that methylation-mediated LGALS4 gene repression may be involved in urothelial tumor progression. PMID: 28423602
- Together, the data demonstrated that surface-bound galectin-4 is a dual function protein-down-regulating cell proliferation and chemokine secretion in galectin-4-expressing colorectal cancer cells on one hand and inducing apoptosis in galectin-4-negative colorectal cancer cells on the other hand. PMID: 28345468
- The carbohydrate-binding site is composed of residues His236, Asn238, Arg240, Asn249, Trp256, Glu259 and Lys261 at the strands S4, S5 and S6. PMID: 26432949
- The data suggests that arm-Gal4 has detrimental effects on Drosophila development and lifespan that are directly dependent upon parental inheritance PMID: 26505429
- The co-expression of galectin-4 and CNT3 proteins is not impaired in inflamed colon from patients with Crohn's disease, thereby anticipating the integrity of this system for drug targeting. PMID: 26481311
- Structural characterization of human galectin 4 C-terminal domain in terms its ligands binding specificity has been reported. PMID: 26077389
- role in basolateral to apical epithelial transcytosis PMID: 25179596
- The results show galectin-4 expression closely associates with hepatocellular carcinoma (HCC) progression and might have potential use as a prognostic biomarker for HCC patients. PMID: 25230111
- Galectin-4 plays an important role in metastatic process of lung adenocarcinoma. PMID: 24339976
- Data indicate that galectin-4 elicits tumor promotion in vitro and in vivo through activation of IL-6/NF-kappaB/STAT3 signaling. PMID: 23378274
- Loss of Galectin-4 is associated with colorectal cancer. PMID: 21064109
- crystals of galectin-4 belonged to space group P6(1)22, with unit-cell parameters a = b = 71.25, c = 108.66 A. PMID: 20445255
- microarray study in sinonasal adenocarcinoma we identified proteins, LGALS4 that is significantly differentially expressed in tumors compared to normal tissue PMID: 19903339
- results suggest that galectin-4 has a unique carbohydrate binding specificity and interacts with O-linked sulfoglycans PMID: 11971864
- SB1a and CEA in the patches on the cell surface of human colon adenocarcinoma cells could be biologically important ligands for galectin-4 PMID: 15546874
- Together, our data propose that interaction between galectin-4 and sulfatides plays a functional role in the clustering of lipid rafts for apical delivery. PMID: 15883199
- Galectin 4 induces surface phosphatidylserine exposure in a carbohydrate-dependent fashion in activated, but not resting, human neutrophils and in several leukocyte cell lines. PMID: 16940423
- not only sulfated glycosphingolipids but also cholesterol 3-sulfate are endogenous ligands for galectin-4 in vivo PMID: 17545668
- chemical analysis of talose-selectivity of galectin-4 and galectin-8 PMID: 18539029
- Data show that the pattern of N-glycosylation of glycoproteins serves as a recognition signal for endocytosed galectin-4, which drives the raft-dependent apical pathway of glycoproteins in enterocyte-like HT-29 cells. PMID: 19192249
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