LAP3 Antibody

說明書

產品詳情

Uniprot No.：

P28838
基因名：

LAP3
別名：

AMPL_HUMAN antibody; Cytosol aminopeptidase antibody; epididymis secretory protein Li 106 antibody; HEL-S-106 antibody; LAP 3 antibody; LAP antibody; LAP-3 antibody; Lap3 antibody; LAPEP antibody; Leucine aminopeptidase 3 antibody; Leucyl aminopeptidase antibody; PEPS antibody; Peptidase S antibody; Proline aminopeptidase antibody; Prolyl aminopeptidase antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Human LAP3
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產品提供形式：

Liquid
應用范圍：

ELISA,WB,IHC
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Cytolosic metallopeptidase that catalyzes the removal of unsubstituted N-terminal hydrophobic amino acids from various peptides. The presence of Zn(2+) ions is essential for the peptidase activity, and the association with other cofactors can modulate the substrate spectificity of the enzyme. For instance, in the presence of Mn(2+), it displays a specific Cys-Gly hydrolyzing activity of Cys-Gly-S-conjugates. Involved in the metabolism of glutathione and in the degradation of glutathione S-conjugates, which may play a role in the control of the cell redox status.
基因功能參考文獻：
1. LAP3 might be a new prognostic factor and be close correlation with glioma cell growth, migration, invasion. PMID: 25453285
2. our results indicated that up-regulated expression of LAP3 might contribute to the proliferation and metastasis of hepatocellular carcinoma PMID: 25120751
3. Overexpression of leucine aminopeptidase 3 contributes to malignant development of human esophageal squamous cell carcinoma. PMID: 24477662
4. results suggest that Lys528 is important for maximal activity of adipocyte-derived LAP by maintaining the appropriate structure of the substrate pocket of the enzyme PMID: 16513116
亞細胞定位：

Cytoplasm.
蛋白家族：

Peptidase M17 family
數據庫鏈接：

HGNC: 18449

OMIM: 170250

KEGG: hsa:51056

STRING: 9606.ENSP00000226299

UniGene: Hs.570791

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