KIF22 Antibody, FITC conjugated

說明書

中文名稱：

KIF22兔多克隆抗體, FITC偶聯(lián)
貨號：

CSB-PA619894LC01HU
規(guī)格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) KIF22 Polyclonal antibody
Uniprot No.：

Q14807
基因名：

KIF22
別名：

A 328A3.2 antibody; KID antibody; KIF 22 antibody; kif22 antibody; KIF22_HUMAN antibody; Kinesin family member 22 antibody; Kinesin like 4 antibody; Kinesin like DNA binding protein antibody; Kinesin like DNA binding protein pseudogene antibody; Kinesin like protein 4 antibody; Kinesin like protein KIF22 antibody; Kinesin-like DNA-binding protein antibody; Kinesin-like protein 4 antibody; Kinesin-like protein KIF22 antibody; KNSL 4 antibody; KNSL4 antibody; OBP 1 antibody; OBP 2 antibody; OBP antibody; OBP1 antibody; OBP2 antibody; Origin of plasmid DNA replication binding protein antibody; OriP binding protein antibody; OTTHUMP00000123406 antibody; SEMDJL2 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Kinesin-like protein KIF22 protein (34-169AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

FITC
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Kinesin family member that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Binds to microtubules and to DNA. Plays a role in congression of laterally attached chromosomes in NDC80-depleted cells.
基因功能參考文獻：
1. Chromokinesin Kid and kinetochore kinesin CENP-E differentially support chromosome congression without end-on attachment to microtubules. PMID: 25743205
2. we conclude that inhibition of KIF22 suppresses cancer cell proliferation by delaying mitotic exit through the transcriptional upregulation of CDC25C. PMID: 24626146
3. Whole-exome sequencing identifies mutations of KIF22 in spondyloepimetaphyseal dysplasia with joint laxity, leptodactylic type PMID: 22152677
4. Recurrent dominant mutations affecting two adjacent residues in the motor domain of the monomeric kinesin KIF22 result in skeletal dysplasia and joint laxity PMID: 22152678
5. in all breast tumor tissues analyzed, variations in the Kid/KIF22 mRNA levels mirrored those seen with SIAH-1 mRNAs. PMID: 20144232
6. These results are consistent with Kid having a role in chromosome congression in vivo, where it would be responsible for the polar ejection forces acting on the chromosome arms. PMID: 12606572
7. its molecular structure and interaction with microtubules PMID: 12692123
8. These results suggest that distinct from its role in chromosome movement, Kid contributes to spindle morphogenesis by mediating spindle microtubules stabilization. PMID: 16176979
9. human Aurora B and Kid are identified as APC/C(Cdh1) substrates PMID: 17726374
10. Association of importin-beta and -alpha with hKid triggers the initial targeting of hKid to mitotic chromosomes; local Ran-GTP-mediated cargo release promotes the accumulation of hKid on chromosomes. PMID: 18268099
11. These data suggest that Kid-mediated anaphase/telophase chromosome compaction prevents formation of multinucleated cells. PMID: 18329364
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相關疾病：

Spondyloepimetaphyseal dysplasia with joint laxity, 2 (SEMDJL2)
亞細胞定位：

Nucleus. Cytoplasm, cytoskeleton.
蛋白家族：

TRAFAC class myosin-kinesin ATPase superfamily, Kinesin family
組織特異性：

Expressed in bone, cartilage, joint capsule, ligament, skin, and primary cultured chondrocytes.
數據庫鏈接：

HGNC: 6391

OMIM: 603213

KEGG: hsa:3835

STRING: 9606.ENSP00000160827

UniGene: Hs.612151

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