KIF22 Antibody, Biotin conjugated
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中文名稱：KIF22兔多克隆抗體, Biotin偶聯
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貨號：CSB-PA619894LD01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) KIF22 Polyclonal antibody
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Uniprot No.：
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基因名：KIF22
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別名：A 328A3.2 antibody; KID antibody; KIF 22 antibody; kif22 antibody; KIF22_HUMAN antibody; Kinesin family member 22 antibody; Kinesin like 4 antibody; Kinesin like DNA binding protein antibody; Kinesin like DNA binding protein pseudogene antibody; Kinesin like protein 4 antibody; Kinesin like protein KIF22 antibody; Kinesin-like DNA-binding protein antibody; Kinesin-like protein 4 antibody; Kinesin-like protein KIF22 antibody; KNSL 4 antibody; KNSL4 antibody; OBP 1 antibody; OBP 2 antibody; OBP antibody; OBP1 antibody; OBP2 antibody; Origin of plasmid DNA replication binding protein antibody; OriP binding protein antibody; OTTHUMP00000123406 antibody; SEMDJL2 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Kinesin-like protein KIF22 protein (34-169AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Biotin
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Kinesin family member that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Binds to microtubules and to DNA. Plays a role in congression of laterally attached chromosomes in NDC80-depleted cells.
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基因功能參考文獻：
- Chromokinesin Kid and kinetochore kinesin CENP-E differentially support chromosome congression without end-on attachment to microtubules. PMID: 25743205
- we conclude that inhibition of KIF22 suppresses cancer cell proliferation by delaying mitotic exit through the transcriptional upregulation of CDC25C. PMID: 24626146
- Whole-exome sequencing identifies mutations of KIF22 in spondyloepimetaphyseal dysplasia with joint laxity, leptodactylic type PMID: 22152677
- Recurrent dominant mutations affecting two adjacent residues in the motor domain of the monomeric kinesin KIF22 result in skeletal dysplasia and joint laxity PMID: 22152678
- in all breast tumor tissues analyzed, variations in the Kid/KIF22 mRNA levels mirrored those seen with SIAH-1 mRNAs. PMID: 20144232
- These results are consistent with Kid having a role in chromosome congression in vivo, where it would be responsible for the polar ejection forces acting on the chromosome arms. PMID: 12606572
- its molecular structure and interaction with microtubules PMID: 12692123
- These results suggest that distinct from its role in chromosome movement, Kid contributes to spindle morphogenesis by mediating spindle microtubules stabilization. PMID: 16176979
- human Aurora B and Kid are identified as APC/C(Cdh1) substrates PMID: 17726374
- Association of importin-beta and -alpha with hKid triggers the initial targeting of hKid to mitotic chromosomes; local Ran-GTP-mediated cargo release promotes the accumulation of hKid on chromosomes. PMID: 18268099
- These data suggest that Kid-mediated anaphase/telophase chromosome compaction prevents formation of multinucleated cells. PMID: 18329364
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相關疾病：Spondyloepimetaphyseal dysplasia with joint laxity, 2 (SEMDJL2)
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亞細胞定位：Nucleus. Cytoplasm, cytoskeleton.
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蛋白家族：TRAFAC class myosin-kinesin ATPase superfamily, Kinesin family
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組織特異性：Expressed in bone, cartilage, joint capsule, ligament, skin, and primary cultured chondrocytes.
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數據庫鏈接：
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