IL1RL2 Antibody

中文名稱：

IL1RL2兔多克隆抗體
貨號：

CSB-PA888016LA01HU
規格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA888016LA01HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human gastric cancer using CSB-PA888016LA01HU at dilution of 1:100
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) IL1RL2 Polyclonal antibody
Uniprot No.：

Q9HB29
基因名：

IL1RL2
別名：

IL 1 receptor related protein 2 antibody; IL 1Rrp2 antibody; IL 36R antibody; IL-1Rrp2 antibody; IL-36 receptor antibody; IL1 receptor related protein 2 antibody; IL1R rp2 antibody; IL1R-rp2 antibody; Il1rl2 antibody; IL1RRP2 antibody; IL36R antibody; ILRL2_HUMAN antibody; Interleukin 1 receptor like 2 antibody; Interleukin 1 receptor related protein 2 antibody; Interleukin-1 receptor-like 2 antibody; Interleukin-1 receptor-related protein 2 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Interleukin-1 receptor-like 2 protein (20-218AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，IL1RL2 Antibody (CSB-PA888016LA01HU)，的標記方式是Non-conjugated。對于IL1RL2 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA888016LB01HU	IL1RL2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA888016LC01HU	IL1RL2 Antibody, FITC conjugated
Biotin	CSB-PA888016LD01HU	IL1RL2 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways. The IL-36 signaling system is thought to be present in epithelial barriers and to take part in local inflammatory response; it is similar to the IL-1 system. Seems to be involved in skin inflammatory response by induction of the IL-23/IL-17/IL-22 pathway.
基因功能參考文獻：
1. Endothelial cells, including dermal microvascular cells, express a functionally active IL-36 receptor. PMID: 27673278
2. All human blood lymphocytes express IL-36R. PMID: 27269181
3. The data identify a novel role for IL-36 signaling in colonic inflammation and indicate that the IL-36R pathway may represent a novel target for therapeutic intervention. PMID: 26813344
4. single nucleotide polymorphism A471T in the Toll-interleukin 1 receptor domain (TIR) of the IL-1Rrp2 that is present in approximately 2% of the human population, down-regulated IL-36R signaling by a decrease of interaction with IL-1RAcP. PMID: 27307043
5. The IL36 receptor (IL1RL2) is an important mediator molecule in the inflammatory response. PMID: 27853811
6. The ubiquitin-binding Tollip protein contributed to IL-36R signaling and increased the accumulation of both subunits of the IL-36R. PMID: 26269592
7. IL36A-IL36R axis is modulated in patients with primary Sjogren's syndrome. PMID: 25902739
8. Expression of IL-1Rrp2 by sone dendritic cell subsets may have an important function in the human immune response in vivo via its role in differentiation of inflammatory Th1 lymphocytes. PMID: 22144259
9. These data provide evidence that IL-38 binds to the IL-36R, as does IL-36Ra.[IL-38, IL-36R] PMID: 22315422
10. IL-1alpha and IL-1beta gene polymorphisms do not act as a strong susceptibility factor for MTLE-HS in individuals of Turkish ancestry PMID: 16546408
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亞細胞定位：

Membrane; Single-pass type I membrane protein.
蛋白家族：

Interleukin-1 receptor family
組織特異性：

Expressed in synovial fibroblasts and articular chondrocytes. Expressed in keratinocytes and monocyte-derived dendritic cells. Expressed in monocytes and myeloid dendritic cells; at protein level.
數據庫鏈接：

HGNC: 5999

OMIM: 604512

KEGG: hsa:8808

STRING: 9606.ENSP00000264257

UniGene: Hs.659863

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