HOXA2 Antibody

中文名稱：

HOXA2兔多克隆抗體
貨號：

CSB-PA010652LA01HU
規格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA010652LA01HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA010652LA01HU at dilution of 1:100

Western Blot
Positive WB detected in: Jurkat whole cell lysate, Mouse liver tissue, Mouse kidney tissue, Mouse stomach tissue
All lanes: Hoxa2 antibody at 2μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 42 kDa
Observed band size: 42 kDa
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品描述：

HOXA2 polyclonal antibody CSB-PA010652LA01HU was produced in rabbit immunized by using the Recombinant Human Homeobox protein Hox-A2 protein (26-124AA) as the immunogen. The target protein HOXA2 is sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Diseases associated with HOXA2 include Microtia, Hearing Impairment, and Cleft Palate and Microtia.
This Rabbit anti-Homo sapiens (Human) HOXA2 Polyclonal antibody was tested in the ELISA, WB and IHC. The non-conjugated IgG got purified by protein G and reached up to 95% in purity. It reacts with the HOXA2 proteins of human or mouse-origin and may be used to detect the endogenous levels of HOXA2 protein.
產品名稱：

Rabbit anti-Homo sapiens (Human) HOXA2 Polyclonal antibody
Uniprot No.：

O43364
基因名：

HOXA2
別名：

AI324701 antibody; homeo box A2 antibody; homeobox A2 antibody; Homeobox protein Hox-1K antibody; Homeobox protein Hox-A2 antibody; Hox-1.11 antibody; HOX1.11 antibody; HOX1K antibody; Hoxa-2 antibody; Hoxa11 antibody; HOXA2 antibody; HXA2_HUMAN antibody; MGC151482 antibody; MGC151484 antibody; RATHOX111A antibody
宿主：

Rabbit
反應種屬：

Human, Mouse
免疫原：

Recombinant Human Homeobox protein Hox-A2 protein (26-124AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，HOXA2 Antibody (CSB-PA010652LA01HU)，的標記方式是Non-conjugated。對于HOXA2 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA010652LB01HU	HOXA2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA010652LC01HU	HOXA2 Antibody, FITC conjugated
Biotin	CSB-PA010652LD01HU	HOXA2 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC

推薦稀釋比：

Application	Recommended Dilution
WB	1:2000-1:5000
IHC	1:20-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
基因功能參考文獻：
1. Performed mutational analysis of TCOF1, GSC, and HOXA2 to determine the mutational features of the 3 genes in Chinese patients with Treacher Collins syndrome. PMID: 27526242
2. The role of HOXA2 gene in dominant isolated microtia and the dysmorphogenetic effect of this gene on ear development PMID: 27503514
3. 5 genomic variants in GSC, HOXA2 and PRKRA were identified through mutational analysis in Chinese patients with microtia. PMID: 28109504
4. The Hoxa2-mediated decay of RCHY1 involves both the 19S and 20S proteasome complexes PMID: 26496426
5. HOXA2 acts as a suppressor or TBP-antagonist to inhibit MMP-9 expression; while methylation-mediated inactivation of HOXA2 in NPC derepresses MMP-9 production and increases invasion of NPC cells. PMID: 24243817
6. we have identified a nonsense mutation (Q235*) in HOXA2 that segregates with bilateral nonsyndromic microtia and hearing loss through three generations of a family in an autosomal dominant pattern. PMID: 23775976
7. Lack of mutations in the coding region of HOXA2 among the sporadic microtia patients. PMID: 20542577
8. A missense mutation in the HOXA2 in a consanguineous iranian family with bilateral microtia was reported. PMID: 18394579
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相關疾病：

Microtia, hearing impairment, and cleft palate (MHICP); Microtia with or without hearing impairment (MCRT)
亞細胞定位：

Nucleus.
蛋白家族：

Antp homeobox family, Proboscipedia subfamily
數據庫鏈接：

HGNC: 5103

OMIM: 604685

KEGG: hsa:3199

STRING: 9606.ENSP00000222718

UniGene: Hs.445239

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