GULP1 Antibody

中文名稱：

GULP1兔多克隆抗體
貨號：

CSB-PA887007LA01HU
規(guī)格：

￥440
圖片：
Western Blot
Positive WB detected in: HepG2 whole cell lysate, Rat heart tissue
All lanes: GULP1 antibody at 2µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 35, 20, 23, 34 kDa
Observed band size: 45 kDa

Immunofluorescent analysis of HepG2 cells using CSB-PA887007LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) GULP1 Polyclonal antibody
Uniprot No.：

Q9UBP9
基因名：

GULP1
別名：

CED6 antibody; Cell death protein 6 homolog antibody; Engulfment adapter protein antibody; Engulfment adaptor PTB domain containing 1 antibody; GULP antibody; GULP; engulfment adaptor PTB domain containing 1 antibody; GULP1 antibody; GULP1_HUMAN antibody; Protein GULP antibody; PTB domain adapter protein CED 6 antibody; PTB domain adapter protein CED-6 antibody; PTB domain adaptor protein CED6 antibody; PTB domain-containing engulfment adapter protein 1 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human, Rat
免疫原：

Recombinant Human PTB domain-containing engulfment adapter protein 1 protein (199-279AA)
免疫原種屬：

Homo sapiens (Human)

標(biāo)記方式：

Non-conjugated

本頁面中的產(chǎn)品，GULP1 Antibody (CSB-PA887007LA01HU)，的標(biāo)記方式是Non-conjugated。對于GULP1 Antibody，我們還提供其他標(biāo)記。見下表：

標(biāo)記方式	貨號	產(chǎn)品名稱	應(yīng)用
HRP	CSB-PA887007LB01HU	GULP1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA887007LC01HU	GULP1 Antibody, FITC conjugated
Biotin	CSB-PA887007LD01HU	GULP1 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA, WB, IF

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:5000
IF	1:50-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點(diǎn)詳情

功能：

May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization and endosomal trafficking of various LRP1 ligands, such as PSAP. Increases cellular levels of GTP-bound ARF6.
基因功能參考文獻(xiàn)：
1. This study highlights and provides new implications for the role of GULP1 associated molecular mechanism(s) in COPD-emphysema development or progression. PMID: 28284325
2. GULP1 only mediates LRP1 transactivation PMID: 23167255
3. The apoptotic engulfment protein Ced-6 participates in clathrin-mediated yolk uptake in Drosophila egg chambers. PMID: 22398720
4. GULP expression positively regulates TGF-beta signaling leading to growth inhibition, this may represent an attractive target to achieve TGF-beta responsiveness in ovarian cells. PMID: 22451657
5. This study identify GULP1 as a novel neuronal amyloid-beta precursor protein interacting protein that alters trafficking and processing of amyloid-beta precursor protein. PMID: 20674096
6. overexpression of GULP1 enhanced the generation of APP CTFs (C-terminal fragments) and Abeta, whereas knockdown of GULP1 suppressed APP CTFs and Abeta production. PMID: 21486224
7. the GULP1 gene and the apoptotic engulfment pathway are involved in schizophrenia in subjects of European ancestry PMID: 19721717
8. Interaction of CED-6/GULP, an adapter protein involved in engulfment of apoptotic cells with CED-1 and CD91/low density lipoprotein receptor-related protein (LRP). PMID: 11729193
9. GULP is a likely downstream molecule in the stabilin-2-mediated signaling pathway and plays an important role in stabilin-2-mediated phagocytosis PMID: 18230608
10. Phosphatidylserine-recognizing SR-BI activates associated GULP; activated GULP induces MAPK phosphorylation; activated MAPK increases GTP-bound Rac1; and activated Rac1 induces a rearrangement of the actin cytoskeleton. PMID: 19122200
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亞細(xì)胞定位：

Cytoplasm. Note=May associate with the cytoplasmic side of the plasma membrane and early endosomes.
蛋白家族：

Ced-6 family
組織特異性：

Widely expressed. Detected in macrophages, pancreas, kidney, skeletal muscle, heart, colon, intestine, lung, placenta and ovary.
數(shù)據(jù)庫鏈接：

HGNC: 18649

OMIM: 608165

KEGG: hsa:51454

STRING: 9606.ENSP00000352047

UniGene: Hs.470887

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