GULP1 Antibody, FITC conjugated
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中文名稱：GULP1兔多克隆抗體, FITC偶聯
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貨號：CSB-PA887007LC01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) GULP1 Polyclonal antibody
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Uniprot No.：
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基因名：GULP1
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別名：CED6 antibody; Cell death protein 6 homolog antibody; Engulfment adapter protein antibody; Engulfment adaptor PTB domain containing 1 antibody; GULP antibody; GULP; engulfment adaptor PTB domain containing 1 antibody; GULP1 antibody; GULP1_HUMAN antibody; Protein GULP antibody; PTB domain adapter protein CED 6 antibody; PTB domain adapter protein CED-6 antibody; PTB domain adaptor protein CED6 antibody; PTB domain-containing engulfment adapter protein 1 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human PTB domain-containing engulfment adapter protein 1 protein (199-279AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：FITC
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
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靶點詳情
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功能：May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization and endosomal trafficking of various LRP1 ligands, such as PSAP. Increases cellular levels of GTP-bound ARF6.
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基因功能參考文獻：
- This study highlights and provides new implications for the role of GULP1 associated molecular mechanism(s) in COPD-emphysema development or progression. PMID: 28284325
- GULP1 only mediates LRP1 transactivation PMID: 23167255
- The apoptotic engulfment protein Ced-6 participates in clathrin-mediated yolk uptake in Drosophila egg chambers. PMID: 22398720
- GULP expression positively regulates TGF-beta signaling leading to growth inhibition, this may represent an attractive target to achieve TGF-beta responsiveness in ovarian cells. PMID: 22451657
- This study identify GULP1 as a novel neuronal amyloid-beta precursor protein interacting protein that alters trafficking and processing of amyloid-beta precursor protein. PMID: 20674096
- overexpression of GULP1 enhanced the generation of APP CTFs (C-terminal fragments) and Abeta, whereas knockdown of GULP1 suppressed APP CTFs and Abeta production. PMID: 21486224
- the GULP1 gene and the apoptotic engulfment pathway are involved in schizophrenia in subjects of European ancestry PMID: 19721717
- Interaction of CED-6/GULP, an adapter protein involved in engulfment of apoptotic cells with CED-1 and CD91/low density lipoprotein receptor-related protein (LRP). PMID: 11729193
- GULP is a likely downstream molecule in the stabilin-2-mediated signaling pathway and plays an important role in stabilin-2-mediated phagocytosis PMID: 18230608
- Phosphatidylserine-recognizing SR-BI activates associated GULP; activated GULP induces MAPK phosphorylation; activated MAPK increases GTP-bound Rac1; and activated Rac1 induces a rearrangement of the actin cytoskeleton. PMID: 19122200
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亞細胞定位：Cytoplasm. Note=May associate with the cytoplasmic side of the plasma membrane and early endosomes.
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蛋白家族：Ced-6 family
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組織特異性：Widely expressed. Detected in macrophages, pancreas, kidney, skeletal muscle, heart, colon, intestine, lung, placenta and ovary.
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數據庫鏈接：
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