GPC4 Antibody

中文名稱：

GPC4兔多克隆抗體
貨號：

CSB-PA009706LA01HU
規格：

￥440
圖片：
Western blot
All lanes: GPC4 antibody at 8µg/ml + Mouse brain tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 63, 55 kDa
Observed band size: 63 kDa

Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA009706LA01HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA009706LA01HU at dilution of 1:100

Immunofluorescent analysis of HepG2 cells using CSB-PA009706LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
其他：

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靶點詳情

產品詳情

產品描述：

In the production of the GPC4 polyclonal antibody, a rabbit was initially immunized with the recombinant human Glypican-4 protein (19-210aa). Afterward, the antibodies were obtained and extracted from the rabbit serum, and subsequently purified using protein G affinity chromatography.

The resulting GPC4 polyclonal antibody possesses a purity level exceeding 95%, indicating that it contains almost no impurities. It has been demonstrated to recognize and bind to GPC4 protein in human and mouse samples. In addition, the versatility of the GPC4 polyclonal antibody has been demonstrated through its successful validation in various applications, such as ELISA, WB, IHC, and IF, indicating its effectiveness in a range of experimental settings.
產品名稱：

Rabbit anti-Homo sapiens (Human) GPC4 Polyclonal antibody
Uniprot No.：

O75487
基因名：

GPC4
別名：

dJ900E8.1 glypican 4 antibody; Glypican proteoglycan 4 antibody; Gpc4 antibody; GPC4_HUMAN antibody; K Glypican antibody; K-glypican antibody; Kglypican antibody; OTTHUMP00000024052 antibody; Secreted glypican 4 antibody; Secreted glypican-4 antibody; UNQ474/PRO937 antibody
宿主：

Rabbit
反應種屬：

Human, Mouse
免疫原：

Recombinant Human Glypican-4 protein (19-210AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，GPC4 Antibody (CSB-PA009706LA01HU)，的標記方式是Non-conjugated。對于GPC4 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA009706LB01HU	GPC4 Antibody, HRP conjugated	ELISA
FITC	CSB-PA009706LC01HU	GPC4 Antibody, FITC conjugated
Biotin	CSB-PA009706LD01HU	GPC4 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:20-1:200
IF	1:50-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Cell surface proteoglycan that bears heparan sulfate. May be involved in the development of kidney tubules and of the central nervous system.
基因功能參考文獻：
1. The T allele of GPC4 may represent a risk factor for Epstein-Barr virus-associated gastric carcinoma. PMID: 27071854
2. According to behavioral studies, downregulation of Gpc4 by Gpc4 siRNA decreased spontaneous seizure frequency, while upregulation of Gpc4 by recombinant Gpc4 overexpression led to a converse result. These findings support the hypothesis that increased expression of Gpc4 in the brain is associated with epileptic seizures. PMID: 27425250
3. serum level elevated in polycystic ovary syndrome and correlated with fat distribution and cardiovascular risk PMID: 26486309
4. Data suggest gender difference in circulating GPC4 levels in nonalcoholic fatty liver disease; GPC4 levels in women appear to correlate with cardiometabolic risk factors (adiposity/body fat distribution, insulin resistance, and arterial stiffness). PMID: 23633195
5. new function of miR-125a by targeting gene glypican-4 in cell growth process PMID: 22644326
6. Findings establish that Gpc4 acts at the interface of extrinsic and intrinsic signal regulation to fine tune stem cell fate. PMID: 22761013
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亞細胞定位：

Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side.; [Secreted glypican-4]: Secreted, extracellular space.
蛋白家族：

Glypican family
數據庫鏈接：

HGNC: 4452

OMIM: 300168

KEGG: hsa:2239

STRING: 9606.ENSP00000359864

UniGene: Hs.58367

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